What is ACTH hormone? Norm in women in the blood andtranscript of analyzes

Content:

  • What is ACTH hormone?
  • Norm hormone in the blood
  • ACTH analysis
  • Increased ACTH Level
  • Reduced ACTH Level
  • Video
  • Normalization of indicators

A substance produced by the anterior pituitary gland is called
ACTH hormone. What it is? In women, ACTH (adrenocorticotropic
hormone) performs the role of “controller” of the activity of several glands and
involved in many processes.

What is ACTH hormone?

Adrenocorticotropic hormone (Acth) is produced in the pituitary gland and
controlled by the hypothalamus. ACTH regulates the secretion of steroid
hormones in the female body, stimulates the synthesis of estrogen –
major female hormones.

Role of ACTH:

  • weight adjustment;
  • control of the rate of lipid metabolism;
  • maintaining normal blood glucose levels;
  • regulation of the adrenal cortex;
  • participation in the synthesis of estrogen;
  • control of aldosterone synthesis;
  • increased action of peptide hormones (prolactin,
    somatotropin).
  • normalization of the menstrual cycle.

That is, thanks to the action of ACTH, the woman’s body copes with
infections, stress, has the ability to conceive a child.

Что такое актг


Important is the ability of ACTH to maintain adequate
cortisol production. Cortisol in the body performs important functions:
relieves pain, helps blood to muscles, normalizes
sugar level, prevents allergic reactions. In the same time
elevated levels of cortisol have negative effects: reduces
immunity, violates digestion, promotes protein breakdown. With
elevated cortisol risk of losing muscle
masses.

Источник: https://ru.wikipedia.org/wiki/Адренокортикотропный_гормон

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Norm hormone in the blood

Adrenocorticotropic hormone levels change over time.
days. The maximum concentration is observed around 7 am
minimal late in the evening. Normally, the content of ACTH
should be in the range of 2-11 pmol / l. Have pregnant
there is a slight increase, it is not considered
deviation.

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ACTH analysis

To determine the concentration of the hormone prescribed analysis
blood from a vein. Indications for the test
are:

  • increased blood pressure;
  • chronic fatigue;
  • hyperplasia of the adrenal cortex;
  • adrenal dysfunction;
  • premature puberty;
  • a large number of pigment spots;
  • acne in adults;
  • obesity;
  • frequent bone fractures;
  • taking corticosteroids;
  • elevated blood glucose levels;
  • surgery to remove adrenal tumors;
  • violation of the menstrual cycle;
  • suspicion of Itsenko-Cushing syndrome.

How to take the ACTH test correctly? Usually the analysis is prescribed for
6-7 day cycle. To obtain reliable indicators, you need to go
preliminary preparation for the analysis:

  • give up alcohol for a day;
  • do not take any drugs for 24 hours;
  • avoid physical exertion on the eve of the test;
  • refuse food and drinks 12 hours before blood donation;
  • 4 hours before analysis do not smoke.

Blood sampling is done in the morning on an empty stomach. To diagnose the syndrome
Itsenko – Cushing’s blood is donated in the evening – at 21-23 hours.


There are two types of test: quick and
long.

  • With быстром сначала берут кровь, затем пациенту вводят
    ACTH substitute and blood sampling.
  • With длительном кровь берут 4 раза: до введения заменителя,
    then after 4, 6, and 8 hours.

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Symptoms and treatment

The result of the study may affect the following
factors:

  • change of time zone;
  • stress;
  • recently moved operations;
  • pregnancy;
  • high temperature;
  • taking insulin, calcium gluconate and other drugs.

About all the nuances should warn the doctor who will
decoding the analysis so that it can make adjustments with
considering all the nuances.

Pathological deviation is normal
reduced or elevated levels of ACTH about 1.6 times.
The remaining fluctuations are minor and are associated with
short-term exposure to external factors. To be sure
results can be retested.

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Increased ACTH Level

For a person, elevated and lowered are equally dangerous.
adrenocorticotropic hormone level.

If the level is increased about 2 times, then this indicates
following pathologies:

  • Синдром Кушинга. With этом гипофиз приобретает
    large size and begins to intensively produce ACTH. As a result
    production of cortisol (stress hormone) increases.
  • Опухоль гипофиза.
  • Болезнь Адиссона. Adrenal glands do not produce
    cortisol, so the pituitary gland produces a large amount of ACTH.
  • Паранеопластический синдром. Pituitary gland reacts
    for growth in other organs (pancreas, lungs)
    increased production of adrenocorticotropic hormone.
  • Синдром Нельсона. Occurs after operational
    adrenal gland removal.
  • Опухоли надпочечников, при которых органы
    produce a large amount of ACTH without taking into account cortisol levels.
  • Надпочечный вирилизм. Increased occurs
    synthesis of male hormones by the adrenal cortex. In women, it
    manifested obesity and body hair male type.


An excess of ACTH and cortisol upsets the metabolism, causing
negative changes in the body. Withзнаки повышенного уровня
ACTH:

  • obesity in the face, neck, abdomen in the absence of fat on
    feet;
  • climacteric hump (fat in the area of ​​7 cervical vertebra);
  • stretch marks on the skin crimson color;
  • a large number of pigment spots;
  • thinned skin of hands;
  • increased blood pressure;
  • arrhythmia;
  • chronic fatigue;
  • tooth decay;
  • cycle violation.

During stress, the level of adrenocotropic hormone can
increase briefly, but it will not cause any external
manifestations. This can happen when a person has experienced stressful
situations:

  • burns;
  • injuries;
  • hypothermia;
  • infectious diseases;
  • bleeding;
  • low carbohydrate diet;
  • experienced fear.

After the elimination of provoking factors, the level
adrenocorticotropic hormone returns to normal.

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Symptoms and treatment

Reduced ACTH Level

No less dangerous is the low level of ACTH. In medicine
indicate the following reasons for the decline:

  • Benign adrenal glands that
    produce cortisol. The patient has obesity, hypertension,
    sugar level rises.
  • Endemic goiter in which thyroid hyperplasia occurs
    glands.
  • Atrophy of the adrenal cortex (secondary hypocorticism). Low
    the content of cortisol provokes a decrease in the production of ACTH.
  • Autoimmune damage to the pituitary gland. Diabetes appears, collapses
    teeth.
  • Injuries to the pituitary and hypothalamus. As a result начинается
    adrenal insufficiency.
  • Inflammatory processes in the pituitary gland (lymphocytic hypophysitis).
    Часто возникает после родов и manifested потерей веса, слабостью,
    dizziness.

Also a slight decrease occurs during menstruation and after
X-ray examination.

The decrease in ACTH level is indicated by the following states:

  • Weight loss for no apparent reason.
  • Digestive disorders (constipation, diarrhea, flatulence).
  • Low glucose.
  • Decreased blood pressure.
  • Weakness, fatigue.
  • Blurred vision
  • Muscle weakness.
  • Early gray hair.
  • Tooth decay.
  • Decrease in body temperature to 36 degrees.
  • Mental disorder (depression, apathy, mental breakdowns).
  • Reduced memory, attention.
  • Hypogonadism (underdevelopment of female genitals).

With возникновении одного или нескольких из вышеперечисленных
symptoms need to consult a doctor.

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