What can tell the total blood protein: normreasons for its decline and increase

Update: December 2018

Total serum protein is the concentration of albumin and
глобулинов  жидкой составляющей крови в сумме, выраженная
quantitatively. This indicator is measured in g / liter.

Protein and protein fractions are composed of complex amino acids. Squirrels
blood take part in various biochemical processes of ours
organism and serve to transport nutrients
(lipids, hormones, pigments, minerals, etc.) or
medicinal constituents to various organs and systems.

They also act as catalysts and perform immune
protection of the body. Total protein is used to maintain a constant pH.
blood circulating media and is actively involved in
coagulation system. Due to protein all the components of the blood
(leukocytes, red blood cells, platelets) are present in serum
suspended state. It is protein that determines the filling.
vascular bed.

The total protein can be judged on the state of hemostasis, because due to
protein blood has characteristics such as fluidity and has
viscous structure. Work depends on these qualities of blood.
heart and overall cardiovascular system.

General blood protein test refers to biochemical
analysis and is one of the main indicators for the diagnosis
various diseases, it is also included in the mandatory list
clinical examinations for some populations.

Norms of protein concentration in blood serum of different age

category Norm / women Norm / Men
Newborns 42-62 g / l 41-63 g / l
Children under 1 year 44-79 g / l 47-70 g / l
Children from 1 to 4 years 60-75 g / l 55-75 g / l
Children from 5 years to 7 years 53-79 g / l 52-79 g / l
Children from 8 years to 17 years 58-77 g / l 56-79 g / l
Adults 22-34 years 75 – 79 g / l 82-85 g / l
Adults 35-59 years old 79-83 g / l 76-80 g / l
Adults 60-74 years 74-77 g / l 76-78 g / l
Over 75 years old 69-77 g / l 73-78 g / l

Determine the total blood protein without fail

  • kidney disease, liver disease
  • acute and chronic infectious processes of various
    of character
  • burns, oncological diseases
  • metabolic disorders, anemia
  • eating disorders and malnutrition, gastrointestinal diseases – to assess
    degree of malnutrition
  • a number of specific diseases
  • as a stage 1 in a comprehensive survey of health
  • to assess the body’s reserves before surgery,
    medical procedures, medications,
    treatment efficacy and prediction of the current

Indications of total blood protein allows to assess the condition
patient, функцию его органов и систем в работе по поддержанию
proper protein metabolism, and determine rationality
power supply. In case of deviation from the normal value, the specialist
назначит дальнейшее обследование для выявления причины diseases,
for example, the study of protein fractions that may show
the percentage of albumin and globulins in serum


Deviations from the norm can be:

  • Relative deviations are associated with changes in the amount of water in
    circulating blood, for example, with infusion infusions or,
    on the contrary, with excessive sweating.
  • Absolute caused by a change in the rate of protein metabolism. They
    may be caused by pathological processes affecting
    the rate of synthesis and breakdown of serum proteins or
    physiological, such as pregnancy.
  • Physiological abnormalities in total serum protein
    blood is not associated with the disease, but may be caused by taking protein
    food, prolonged bed rest, pregnancy, period
    lactation or change in water load and severe physical

What does the decrease in the concentration of total protein in serum

Low blood protein levels are called
hypoproteinemia. This condition can occur when
pathological processes, such as:

  • parenchymal hepatitis
  • chronic bleeding
  • anemia
  • urine protein loss in kidney disease
  • diets, starvation, insufficient protein intake
  • enhanced protein breakdown associated with metabolic disorders
  • интоксикации различного of character
  • fever

Separately, it should be noted physiological hypoproteinemia, i.e.
состояния не связанные с протеканием патологических processes
(disease). A decrease in total protein in the blood can be observed:

  • in the last trimester of pregnancy
  • during lactation
  • with prolonged heavy loads, for example when preparing
    athletes to compete
  • with prolonged hypodynamia, for example, in bedridden patients

Symptomatically, a decrease in total blood protein concentration may
express the appearance of tissue edema. This symptom usually appears.
with a significant decrease in total protein, below 50 g / l.

О чем говорит повышение общего белка в сыворотке blood?

Significant increase in total blood protein concentration
called hyperproteinemia. This condition cannot be observed.
with normal physiological processes, which means develops
only in the presence of pathology in which education occurs
abnormal proteins.

For example, an increase in total protein in the blood may indicate
о  развитии инфекционного diseases или состояния, при
dehydration (burns, vomiting, diarrhea and

The increase in total protein cannot be accidental, in this case
It is recommended that you seek medical advice as soon as possible.
further examination. Only a specialist can install
cause, make the correct diagnosis and prescribe effective

Diseases in which there is a decrease and increase in overall
blood protein:

Low total blood protein Elevated total blood protein
  • Surgical interventions
  • Tumor processes
  • Liver diseases (hepatitis, cirrhosis, tumors and
  • Glomerulonephritis
  • Diseases of the digestive tract (pancreatitis, enterocolitis)
  • Острые и chronic bleeding
  • Burn disease
  • Thyrotoxicosis
  • Anemia
  • Bst Wilson-Konovalov (heredity)
  • Pleurisy
  • Ascites
  • Fever
  • Diabetes
  • Injuries and Polytrauma
  • Infusion therapy (infusion of a large volume of fluid)
  • Intoxication poisoning
  • Myeloma
  • Rheumatoid arthritis
  • Chronic hepatitis
  • Cirrhosis of the liver
  • Systemic lupus erythematosus
  • Limforganulomatosis
  • Scleroderma
  • Extensive burns
  • Massive bleeding
  • Diabetes insipidus
  • Poisoning and infections accompanying vomiting and diarrhea
  • Intestinal obstruction
  • Nephritis
  • Cholera
  • Sepsis
  • Malignant tumors
  • Allergies

How to prepare for the delivery of biochemical analyzes?

  • Special training delivery of biochemical analyzes, including
    total protein does not require, but remember that they surrender
    in the morning on an empty stomach. The previous meal should be no later than 8, and
    better than 12 hours before the procedure.
  • The day before the test is better not to take a lot of protein
    of food
  • Do not drink too much liquid.
  • Avoid heavy physical exertion.

All these factors can affect the true result of the analysis in
one side or the other.

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