Popular antidepressants increase riskdementia development

Update: February 2019

Common drugs for depression, Parkinson’s and
недержания мочи способны увеличить риск dementia development.
British scientists urge to use these medicines only in
really necessary cases.

Dementia is a group of symptoms that includes memory impairment,
thinking and social interaction. In severe forms leads to
impossibility of self-service. One form of dementia is illness.


The study was conducted by scientists from the University of East Anglia.
(University of East Anglia). The authors analyzed the medical
cards of 40,000 patients with dementia in the age group of 65 years and
about 300,000 cards of people not suffering from dementia. To analysis
all drugs prescribed in the last 20 years for
clarify the connection between taking anticholinergic drugs and
subsequent development of dementia.

Антидепрессанты и деменцияIn particular, were considered
effects of treatment with 4 drugs:

  • Amitriptyline, a tricyclic antidepressant prescribed by
    to relieve pain and improve sleep.
  • Paroxetine, a selective reuptake inhibitor
  • Oxybutinin, a drug for urinary incontinence.
  • Procyclidine, a drug for Parkinson’s disease.

Лечение данными препаратами увеличивает риск dementia development
by 30%. If initially the risk of dementia in the analyzed group
population was 10%, then with prolonged treatment, it increased to
13%. At the same time, antihistamine and gastroenterological
drugs from the anticholinergic group turned out to be

Ученые резюмируют: проблема особенно актуальна
Now, when many people take 5 or more drugs
at the same time. Many of them have anticholinergic effects. With
prescribing therapy should weigh the possible risks of dementia and
reduce the drug load. Moreover, you can not use
these drugs without a prescription and independently increase
their dose.

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