Update: October 2018
Nimesil is an analgesic and antipyretic drug with
pronounced anti-inflammatory effect. Refers to the group
non-hormonal anti-inflammatory drugs from the class
The active ingredient of Nimesil is nimesulide, which provides
powerful system action. Effective in the treatment of inflammatory
feverish conditions, infectious and rheumatic processes,
pronounced pain syndrome of various etiologies.
Exceeds in action popular drugs from the group of NSAIDs
(ibuprofen, diclofenac), working directly in the outbreak
inflammation, but it has a wide range of contraindications and
It should be understood that with all its high efficiency
Nimesil is intended for symptomatic therapy, acting on
moment of use and without affecting the etiological cause
Farmgroup: NPVS – Non-steroidal anti-inflammatory
The composition of the drug
- Active ingredient: Nimesulide 100 mg;
- Excipients: sucrose, ketomacrogol 1000,
maltodextrin, anhydrous citric acid, orange
Nimesil is produced in the form of granular granules for preparation
oral suspensions having a light yellow color and
orange smell. In one paper laminated bag – 2
gram of powder. Cardboard packs on 9, 15, 30 bags.
- 1 bag of 22-40 rubles,
- 30 bags 611-890 rub.
Nimesulide has a pronounced effect on metabolism.
arachidonic acid, inhibiting mainly cyclooxygenase-2.
Owing to these processes, the biosynthesis of prostaglandins decreases,
mediators of inflammatory and allergic reactions, and
smooth muscle organs.
The drug quickly blocks the release of histamine from mast cells,
slows down the synthesis of metalloprotease, elastase and collagenase,
thus protecting the cartilage from destruction. Suppresses
release of tumor necrosis factor alpha, reducing the effect
kinin, causing expansion of the vascular wall. Reduces production
neutrophils of superoxide anions and the formation of free
radicals playing an important role in the development of inflammatory
Due to the nature of this dosage form of nimesulide
Nimesil’s effectiveness develops rapidly and continues throughout
According to the instructions for use Nimesila after taking
suspension the drug is rapidly absorbed through the digestive tract, reaching
maximum therapeutic concentration after 2-3 hours.
It is characterized by a high bond with blood proteins, up to 97.5%, easy
passes through histohematogenous barriers.
Metabolism of the drug occurs in the liver using P450 (CYP)
2C9: cytochrome isoenzyme. The main metabolite is hydroxynimesulide,
pharmacologically active nimesulide derivative. Displayed through
About 50% of the accepted amount of Nimesila is displayed
by the kidneys.
Indications for use
- Treatment of osteochondrosis, rheumatoid arthritis as
- back pain, back pain;
- pain accompanying injuries, sprains, inflammation and
dislocation of the joints;
- postoperative period.
- Treatment of acute pain symptom
- Symptomatic treatment of gynecological, vascular and
- Inflammatory diseases with fever (except
SARS and colds).
|Contraindications:||It is prescribed with caution in the following pathologies and
Before using the contents of the bag (granules) pour in
glass and add about 100 ml of water, mix to obtain
homogeneous suspension. It’s impossible to store the prepared solution, therefore
Prepare immediately before use.
- Accepted after a meal, 1 sachet (pre-dissolved) 2
times a day.
- The maximum duration of receiving Nimesil is 15 days,
however, in order to eliminate the risk of adverse reactions optimal
is the appointment of the drug short course (5-7 days).
- Teenagers from 12 to 18 years old take Nimesil in the recommended above.
- The decision on dose adjustment for elderly patients is made.
Patients with renal insufficiency (mild and moderate
degree) does not require correction of the dose and intervals of administration. During
clinical trials in these patients there are elongated in
twice the time interval to reach maximum concentration
blood nimesulide and the half-life of active metabolites
substances that fall within the pharmacokinetic limits
- Hematopoietic system: anemia and eosinophilia may develop,
hemorrhagic syndrome; very rarely – patient,
thrombocytopenia and thrombocytopenic purpura.
- Allergic reactions: itching, skin rash,
excessive sweating; less likely to develop stronger reactions
hypersensitivity – dermatitis, erythema, urticaria,
angioedema, anaphylactoid reactions, syndrome
Stevens Johnson and Lyell.
- CNS: dizziness; less likely to develop – a feeling of fear, night
nightmares, nervousness, drowsiness, headache,
- Bodies of vision: blurred vision is rarely observed.
- CCC: tachycardia, arterial hypertension, lability are likely
blood pressure, tidal sensation.
- Respiratory: sometimes shortness of breath; less often – bronchospasm,
exacerbation of bronchial asthma.
- Digestive organs: often develop vomiting and nausea, as well as
diarrhea, constipation and flatulence, gastropathy, dyspepsia,
abdominal pain, tarry stools, stomatitis. Very rarely
gastrointestinal bleeding occurs, ulcerative
damage to the gastrointestinal tract, hepatitis, cholestasis, jaundice, an increase
- Urinary system: rarely hematuria, dysuria,
urinary retention; extremely rarely renal formation
deficiency, interstitial nephritis, oliguria.
- General disorders: malaise, asthenic condition, less often –
- Blood change: hyperkalemia is very rare.
Symptoms of an overdose are: drowsiness, apathy, nausea and
vomiting, pain in the epigastric region, may develop
gastrointestinal bleeding. In rare cases, celebrated
high blood pressure, acute renal develops
insufficiency, breathing is suppressed down to coma and develop
прочие анафилактоидные reaction. When started on time
symptomatic therapy all phenomena are reversible.
An individual risk assessment of the use of Nimesil therapy is required.
while taking angikoagulyantov (warfarin), antiplatelet agents
(Clopidogrel), glucocorticosteroids (prednisone), selective
serotonin reuptake inhibitors SSRIs (Citalopram,
|Drug group||Possible reactions when used together with Nimesil|
|Glucocorticosteroids||Increased risk of gastrointestinal bleeding and development
|Antiplatelet agents, SSRIs||Increased risk of gastrointestinal bleeding|
|Anticoagulants||Increased risk of bleeding|
|Antihypertensive drugs||Weakening action, ухудшение функции почек|
|Lithium preparations||Reduced clearance of lithium|
|CYP2C9 isoenzyme substrates||Decreased blood concentration|
|Cytostatics||Increased toxic effects|
According to the instructions of Nimesil if the patient is at risk
возникновения ulcers, желудочно-кишечных кровотечений, а также при
simultaneous treatment with the above drugs, therapy
Nimesilom start with the lowest dose, watching the state
the patient. With the slightest adverse or undesirable reactions, treatment
- Nimesil contains sucrose, which should be considered
patients with diabetes mellitus: in 1 sachet 0.15-0.18 XE.
- With the occurrence of ARVI and colds during therapy
Нимесилом лечение stop.
- Care should be taken during the treatment with Nimesil when
driving a car and precise, dangerous jobs.
In hermetically sealed bags – 2 years. In case of violation
the integrity of the packaging drug can not be used.
Analogsчными по составу, с действующим веществом nimesulide
The following medications are: Nemuleks, Aktasulid,
Aponil, Ameolin, Aulin, Nimesulid, Nimulid, Sulaydin, etc.
Some of them have several times lower cost at the same
efficiency with Nimesil. Difference granules for cooking
suspensions from tablets (cheaper) only in the fact that the effect
it comes a little faster due to faster absorption
suspension, and the efficiency remains the same.
100 mg. 20 pieces 70 rub.
Nimesulide Тева 100 mg. 20 pieces 170 rub.
100 mg. 20 pieces 200 rub.
гранулы для суспензии 100 mg. 30 pieces 500 rub.
tab. для рассасывания 100 mg. 20 pieces 200-250 rub., Suspension 60
100 mg. 20 pieces 170 rub.
100 mg. 20 pieces 230 rub.
Автор: врач-гигиенист, эпидемиолог