Update: October 2018
Mydocalm belongs to the group of muscle relaxants
means and has a direct impact on the different structures of the nervous
system. Widely used in neurological diseases, among
symptoms which present increased tone of striated
Also used to treat angiopathy, in preparation for
operational interventions for the relief of emergency conditions.
It is characterized by rapid removal of smooth muscle spasm and significant
reduced sensitivity of nerve endings.
The active basis of the drug is tolperisone hydrochloride.
– direct muscle relaxant.
Farmgroup: Myorelaxant of the central (direct) action.
The composition of the drug
Available in two dosage forms:
- Tablets of 50 and 150 mg for oral administration;
- Solution for parenteral intramuscular or intravenous
Tablets, 50 mg
|50 mg tolperisone hydrochloride||0.73 mg citric acid monohydrate, 0.8 mg colloidal
silicon dioxide, 1.7 mg stearic acid, 4.5 mg talc, 14 mg
MCC, 29.77 mg of corn starch, 48.5 mg of monohydrate
|0.045 mg of colloidal silicon dioxide, 0.244 mg of titanium
диоксида, 0,392 мг моногидрата lactose, 3,927 мг гипромеллозы
Tablets, 150 mg
|150 mg tolperisone hydrochloride||2.19 mg citric acid monohydrate, 2.4 mg colloidal
silicon dioxide, 5.1 mg stearic acid, 13.5 mg talc, 42 mg
MCC, 89.31 mg of corn starch, 145.5 mg of monohydrate
|0.089 mg of colloidal silicon dioxide, 0.487 mg of titanium
диоксида, 0,785 мг моногидрата lactose, 0,785 мг макрогола 6000,
7,854 mg of hypromellose
|100 mg tolperisone hydrochloride, 2.5 mg lidocaine
|methyl parahydroxybenzoate (E218), monoethyl ether
|Water for injections|
Release form, price
- Tablets with a film cover of almost white color, round
biconvex shape, having a characteristic smell and engraving 150
or 50, 30 pieces in a pack.
- Mydocalm 50 mg – price 277-392 rubles,
- Mydocalm 150 mg – price 318-419 rubles.
- Solution для инъекций, прозрачного цвета со специфическим
a smell in sterile ampoules on 1 ml, 5 ampoules in a pack. Price –
- The action of tolperisone, which has a high affinity for the nervous
tissue, not well understood.
- Being a centrally acting muscle relaxant, has
local anesthetic and membrane stabilizing effect, inhibits
passage of nerve impulses in motor neurons and primary
afferent fibers from the internal organs to the central nervous
the system. This leads to blocking of mono and polysynaptic
- Promotes secondary inhibition of mediator release by
suspension of calcium ions in the nerve synapses.
- Enhances peripheral circulation through expansion
vessels, has antispasmodic and adrenoblokiruyuschee effect.
Снижает гипертонус, спастичность и ригидность muscle
- Improves the activity of voluntary movements, increasing them
- Reduces the threshold of pain sensitivity.
- Solution для инъекций за счет содержания лидокаина устраняет
soreness and swelling at the injection site.
Pills. Active substance хорошо адсорбируется через ЖКТ,
after 0.5-1 hours, the maximum effective is reached
blood concentration, duration of action 4-6 hours.
Bioavailability of the dosage form according to the instructions for
Mydocalm’s use is about 20%.
Solution. The therapeutic maximum in blood is reached through
30-45 minutes after parenteral administration of the drug
drug. The half-life is about 1.5 hours.
Metabolism and excretion. Tolperisone hydrochloride is metabolized
liver and kidneys, excreted in the urine (99%) in the form of metabolites.
Lidocaine is metabolized by the liver and excreted in the bile.
Indications for use
- Hypertonicity and spasticity of skeletal muscles on the background of organic
lesions of the central nervous system (after a stroke, multiple sclerosis, lesions
pyramidal system, spinal cord damage, toxic or
viral inflammation of the spinal cord and brain, etc.)
- Diseases with muscular dystonia
- The recovery period after orthopedic, surgical and
- Diseases occurring with the obliteration of blood vessels: obliterating
atherosclerosis, Raynaud’s syndrome
- Vascular innervation disorders
- Myogenic contractures and muscle spasticity due to
pathologies of the musculoskeletal system (spondylosis, lumbago with sciatica,
arthrosis of large joints, cervical syndrome);
- Non-inflammatory brain diseases with
muscle tone disorders (infantile paralysis)
- Pain on the background of hemorrhoids
- Menstrual pain
- Uterus tonus threatening miscarriage
- Renal colic
Contraindications and restrictions
- Myasthenia gravis;
- Hypersensitivity to the drug;
- Convulsive activity;
- Parkinson’s disease;
- Chronic severe renal and hepatic failure
- Drug addiction;
- Acute psychosis;
Solution для инъекций
The duration of treatment is not indicated in the instructions, because
determined by the doctor.
Solution для инъекций
Hyperemia of the skin at the injection site (when applying
The drug is non-toxic at a therapeutic dose and
much higher than that. In some cases, receiving 300-600
mg tablet form can lead to irritability.
Significant overdose of parenteral solution
Mydocalm leads to the development of ataxia, difficulty breathing,
convulsions down to stop breathing.
- With the introduction of the solution Myodocalm can not mix it in one
syringe with other drugs.
- Acceptable combination of Mydocalm with sedatives,
sleeping pills and alcohol containing drugs
- If necessary, the appointment of other drugs from the group
muscle relaxants solved the question of reducing the daily dose
Enhances the effect of the following groups of drugs:
- Agents for general anesthesia;
- Muscle relaxants with peripheral action;
- Psychotropic drugs;
- Vegetotropic funds.
To avoid complications and undesirable effects, one should strictly
comply with the dosage. Does not affect driving ability
Analogs – muscle relaxants
- Tolperisone – Mydocalm, Tolperisone
- Tizanidine – Sirdalud, Tizalud, Tizanil
50 mg. 30 pieces 150-200 rubles
150 mg. 30 pieces 180 rub.
2mg 30 pieces 240 rub
2 mg. 30 pieces 140 rub
2mg 30 pieces 170 rub.
Автор: врач-гигиенист, эпидемиолог