Miramistin spray and ointment: instructions forapplication, indications, dosage

Update: October 2018

Miramistin – a drug from the group of cationic antiseptics,
anti-inflammatory, antimicrobial and local
immunoadjuvant action. Antiseptic has a destructive
effects on various pathogens – viruses,
protozoa, fungi and bacteria: the drug destroys the outer shell
microorganisms and thus leads to their death. Local
immunostimulating effect is associated with the activation of phagocytic cells
(macrophages and phagocytes).

The instructions for use Miramistin indicated that this
antiseptic intended for local, outdoor use.
Miramistin’s broad spectrum of action against aerobic and anaerobic
bacteria, including nosocomial bacterial strains with
antimicrobial resistance and pathogens
genital infections, explains the widespread use of the drug.
Use of Miramistin for prophylactic purposes is prescribed when
burns, wounds to prevent them from becoming infected and speeding up
regeneration. It is noteworthy that the drug does not damage the granulation and
Living skin cells do not cause allergies and irritation.

Farmgroup: Antiseptic for local and external use.

Composition, physico-chemical properties, price

Dosage form – a solution of 0.01%, clear, colorless,
Foams with shaking. Available in 50, 150 or 500 ml,
packed in a polyethylene bottle with a urological applicator (50
ml) or spray nozzle (Miramistin Spray) (150 ml).

solution / spray ointment
Current basis: Composition (per 1 l of solution):
benzyldimethyl myristoylamino propylammonium chloride monohydrate, 100
mg;

Также выпускается мягкая лекарственная форма: Мирамистин ointment, в
instructions for use of which the following composition is indicated:

1 g of ointment – 5 mg of miramistin;

Auxiliary substance: purified water to a volume of 1 l. propylene glycol, disodium edetate, macrogol 400, 1500 and 6000,
Proxanol 268, purified water.
Price:
  • 50 ml: 180 – 230 rubles;
  • 150 ml: 320-350 rubles;
  • 500 ml: 730-880 rubles.

Available in banks of 1000 grams or in tubes of 15 and 30 grams.

Price: 80-100 руб. Produced in Ukraine, in Russian
Pharmacies find difficult.

pharmachologic effect

The drug has a pronounced disastrous effect in
respect:мирамистин инструкция

  • Gram-negative (Escherichia coli, Pseudomonas aeruginosa,
    Klebsiella spp. etc.) and gram-positive (Staphylococcus spp.,
    pneumoniae, Streptococcus spp. and others) organisms;
  • nosocomial bacterial strains;
  • fungi of the genus Penicillium, Aspergillus, yeast (Torulopsis
    gabrata, Rhodotorula rubra, etc.) and yeast-like (Candida krusei,
    albicans, tropicalis, etc.), dermatophytes (Trichophyton
    mentagrophytes, verrucosum, schoenleini, violacent, etc.);
  • drug-resistant fungi
    chemotherapeutic series;
  • viruses, including the causative agent of herpes, immunodeficiency
    person;
  • STI pathogens (Treponema spp., Chlamydia spp., Neisseria
    gonorrhoeae, Trichomonas vaginalis, etc.);

Miramistin has a number of positive effects:

  • Prevents infection of burn surfaces and wounds;
  • Accelerates tissue regeneration;
  • Stimulates local protection by activating digestive and
    phagocyte absorption function;
  • Potentiates monocyte-macrophage system;
  • It is characterized by hyperosmolar activity, stopping
    perifocal and wound inflammation;
  • Promotes absorption of purulent exudate, thereby accelerating
    dry scab formation;
  • Does not destroy the marginal epithelization of the wound surfaces.

Pharmacokinetics

Not absorbed through the wound surface, skin and mucous membranes during
local application.

Indications

Solution (Spray)

In surgical and trauma practice:

  • therapy of purulent wounds and prevention of suppuration;
  • treatment of purulent-inflammatory pathologies of the musculoskeletal
    apparatus.

In gynecological and obstetric practice:

  • prevention and therapy of suppurative postpartum trauma, wound
    surfaces in the vagina and perineum;
  • treatment and prevention of female inflammatory processes
    sexual sphere, such as endometritis, vulvovaginitis.

In combustiology:

  • treatment of burns 2 and 3A degree (deep and superficial);
  • preparation of burn surfaces for dermatoplasty;

In dermatology and venereology:

  • treatment and prevention of dermatomycosis, pyoderma and candidiasis
    skin, mucous and mycosis of feet;
  • individual prevention of STIs (syphilis, chlamydia,
    gonorrhea, genital herpes, etc.);

In urology:

  • complex therapy of urethroprostatitis and urethritis in acute and
    chronic course with specific and non-specific
    nature

Application in dentistry:

  • prevention and treatment of infectious and inflammatory pathologies
    oral cavity: gingivitis, stomatitis, periodontitis,
    periodontitis;
  • treatment of removable dentures.

In otolaryngology:

  • complex therapy of otitis, tonsillitis, sinusitis, laryngitis
    (acute and chronic);
  • complex therapy of acute pharyngitis or exacerbations of XP.
    tonsillitis in children 3-14 years.

Ointment

Use in surgery:

  • therapy of infected wound surfaces in wound phase 1
    process (decubitus, fistula, purulent foci, trophic ulcers);
  • prevention of re-infection of healing wounds in 2
    phase.

Application in combustiology:

  • Therapy of burns 2-3A degrees, both superficial and
    deep as well as frostbite;
  • in the period of preparation of burn surfaces for skin
    plastic.

Application in dermatology:

  • Therapy of streptocic and staphylodermia, mucous candidosis and
    skin, mycoses of large skin folds and feet, keratomycosis and
    onychomycosis.

For preventive purposes:

  • prevention of infection with minor injuries.

Contraindications

It is impossible to apply Miramistin in the form of a solution with increased
sensitivity. Not used to treat children under 3
years old.

Ointment также не применяется при повышенной чувствительности к
constituents. Children under one year and in general in pediatric practice
ointment не применяется.

Data on the use of Miramistin in the period of breastfeeding
are absent, while a solution may be prescribed during pregnancy
Miramistina.

Solution dosage

For adults

Application in traumatology, combustiology, surgery with
prophylactic and therapeutic purpose: irrigate the surface
burns, wounds, tamponing of fistula and wounds (not tight), fix
sterile tampons soaked in solution. The multiplicity of procedures – 2-3
times during the day, about 3-5 days in a row. For drainage
cavities and wounds daily consumption of the drug is 1000 ml.

Use in gynecology, obstetrics for the purpose of prevention
postpartum infections: irrigate the vagina 5-7 days before
delivery in labor after each vaginal examination and in
the postpartum period: 50 ml per 1 tampon, 2 h, 5 days exposure
contract.

At delivery by caesarean section process
vagina before surgery. During the intervention – process
uterine cavity and incision. After surgery, swabs are inserted into the vagina,
soaked with Miramistin for 2 hours for 7 days.

Treatment of diseases of the inflammatory nature of the course, 2
of the week. Apply vaginal swabs and drug
electrophoresis.

To prevent sexually transmitted infections, you must use
Miramistin no later than 2 hours after intercourse. Bottle Contents
gently injected into the urethra with an exposure of 2-3 minutes: men 2-3 ml,
women 1-2 ml + 5-10 ml in the vagina. After the introduction of the solution
preferably not to urinate for 2 hours
conduct external genital hygiene, as well as treat
Miramistin skin of the inner thighs, the pubic area and
genitals.

Combined therapy of urethritis and urethroprostatitis: 2-3 ml
the drug is injected into the urethra at intervals of 1-2 times per day.
Course 10 days.

Application in otolaryngology. In the treatment of purulent sinusitis with
puncture of the maxillary sinus – washing the cavity sufficiently
the amount of the drug (to clean water).

For throat: treatment of tonsillitis, laryngitis and pharyngitis.
Rinse or irrigate with a special
spray nozzles: 2-3 clicks on 1 procedure (approximately 10-15
ml), 3-4 times a day.

Use in dentistry – treatment of periodontitis, gingivitis,
stomatitis. Rinsing the oral cavity with the drug in the amount of 10-15 ml
3-4 times a day.

For kids

For the treatment of acute pharyngitis or exacerbation of chronic
tonsillitis – pharynx irrigation using a spray nozzle:

  • children 3-6 years old: a single press with multiplicity 3-4 times a day
    (3-5 ml per procedure);
  • children 7-14 years old: double pressing with multiplicity 3-4 times a day
    (5-7 ml per procedure);
  • children from 14 years: three or four times pressing 3-4 times a
    day (10-15 ml per procedure).

Duration of application is from 4 to 10 days.

Ointment dosage

Ointment наносят на предварительно обработанную антисептиком
surface, top dressing or dressing applied.
Тампонами, пропитанными ointmentю, заполняют свищи и полости гнойных
wounds.

In phase 1 of the wound process – once a day, in phase 2
once within 1-3 days. The course of treatment is determined by the speed
cleansing purulent wounds and tissue regeneration.

В дерматологической практике – ointment наносят на пораженные
plots with a thin layer several times a day. Can be impregnated
sterile dressing and apply on damage (1-2 times per day).
Применяют до 6 недель contract.

Rules of use of Miramistin

The drug is completely ready for use.

Using a spray bottle:

  1. remove the cap;
  2. remove the nozzle from the package and attach it to the vial;
  3. activate the sprayer by pressing it 2 times.

Adverse reactions

In some cases, there may be a burning sensation at the site of application.
solution that disappears after 15-20 seconds. Development is possible
local allergic reactions.

Soap solutions inactivate the action of the ointment.

Overdose

No data available.

Drug interactions

In combination with antibiotics, their enhancement is noted.
antibacterial properties.

Analogs

Analogues of the composition of the drug does not exist. Conditional analog
pharmacological action and indications can be considered
Chlorhexidine, however, Miramistin is more modern
has a wider spectrum of action and a smaller
number of contraindications.

Автор: врач-гигиенист, эпидемиолог

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