Milgamma: tablets instructions,solution, indications, side effects, treatment

Update: October 2018

Milgamma belongs to the group of vitamin-containing medicinal
the means playing a significant role in fast course
regenerative processes of the nervous tissue after pathological
changes, and are prescribed for diseases of the nervous system
degenerative and inflammatory nature. Milgamma
has proven to be an effective drug in therapy
neurological diseases and pathologies of the musculoskeletal
apparatus.

Farmgroup: B complex of vitamins

The composition of the drug, physico-chemical properties, price

The drug is available in two dosage forms: dragee
(Milgamma композитум) и раствор. Dragee is intended for
oral administration, and the solution – for deep injection into the muscular
the cloth. B vitamins stabilize the function of the central nervous system, activate
blood circulation and have a slight analgesic effect.

Dragee

Solution

Main substance
  • 100 mg of vitamin B6 (pyridoxine hydrochloride);
  • 100 mg benfotiamina

  • Vitamin B1 (thiamine hydrochloride): in 1 ml of solution – 50 mg or
    1 ampoule – 100 mg;
  • Vitamin B6 (pyridoxine hydrochloride): 50 mg in 1 ml of solution
    или в 1 ampoule – 100 mg;
  • Vitamin B12 (cyanocobalamin): in 1 ml of solution – 500 μg or in 1
    ampoule – 1 mg;
  • Lidocaine hydrochloride: in 1 ml of solution – 10 mg or in 1 ampoule –
    20 mg
Excipients Sodium carboxymethylcellulose, microcrystalline cellulose
lyric, aerosil, sucrose, povidone, talc, fatty glycerides
acids, shellac, acacia powder, calcium carbonate, titanium dioxide,
glycerol, polyethylene glycol-6000, corn starch, twin-80,
glycolic wax

Бензиловый спирт — 40 мг, полифосфат натрия — 20 mg, гидроксид
sodium – 12 mg, potassium hexacyanoferrate – 0.2 mg, water for injection
– up to 2 ml

Physicochemical properties Dragee белого цвета Solution розовой окраски
Packaging 15 dragees in mesh strip packages, 2 or 4 each
packing in carton
On 2 ml of a preparation in ampoules from dark glass, on 5 or 10
ampoules in cell packs or carton pallets, 1, 2 or 5 each
packs in a carton
Price
  • 30 pills – 640-680 rubles
  • 60 tablets – 1100-1440 rubles
  • 5 amp. 250-280 rubles
  • 1 amp 470-550 rub

 pharmachologic effect

Milgamma является комбинированным препаратом, действующий
composition of which is represented by vitamins of group B:

  • Vitamin B1 is a regulator of protein and carbohydrate
    cellular metabolism, and also takes part in the metabolism of fats.
    It is characterized by an antioxidant effect, regulates
    nerve impulses. Has an analgesic effect due to
    influence on the transmission of excitation.
  • Vitamin B6 is a cofactor of many enzymes that
    act in the nervous tissue. Into the decarboxylation,
    transamination and deamination of amino acids. Prevents
    the accumulation of ammonia in the tissue involved in the formation of neurotransmitters
    (norepinephrine, dopamine, epinephrine, GABA and histamine).

Milgamma в таблетках: Ускоряет восстановление нервной ткани.
Vitamins B6 and B1 are able to potentiate the action of each other. AT
составе драже витамин AT1 представлен бенфотиамином, жирорастворимой
form of vitamin.

Milgamma Prick: Accelerates inflammatory and degenerative
pathology of nervous tissue and musculoskeletal system, improves
the function of the nervous system as a whole. Кроме AT1 и AT6 в состав входит
ATитамин AT 12 , который принимает непосредственное участие в
the formation of the myelin sheath, activates hematopoiesis, contributes to
reducing pain arising from peripheral nerve damage
system. Accelerates nucleic acid metabolism. Lidocaine possesses
local anesthetic effect, providing all kinds of anesthesia
(infiltration, terminal, conductive).

Pharmacokinetics

  • Dragee — после перорального приема бенфотиамин эффективно
    absorbed from the intestines, reaching a maximum concentration in
    blood less than 1 h. Benfotiamin accumulates in the cells in
    five times more active than the water-soluble form of thiamine. After
    biotransformation processes in the form of thiamine diphosphate kinetics are not
    different from water soluble thiamine.
  • Solution — при внутримышечном введении тиамин быстро и
    effectively absorbed by entering the blood. 15 minutes after
    the introduction of 50 mg of the drug is observed concentration of thiamine in the blood
    up to 484 ng / ml. Thiamine is unevenly distributed in the body: the most
    high concentration is observed in erythrocytes – 75%, whereas
    blood plasma concentrates up to 10% of the vitamin. Penetrates through
    placenta and blood-brain barrier. Pyridoxine when
    intramuscular injection also quickly enters the systemic circulation,
    evenly distributed in the body, including the brain.
    Pyridoxine acts as a coenzyme by binding to plasma proteins.
    blood up to 80%.

Metabolism and excretion

Thiamine metabolites are pyramine, thiamine carboxylic acid and
other substances. Thiamine persists in the body less than others
vitamins. ATыводится с мочой. Pyrodoxine forms a depot in the liver,
oxidizing to 4-pyridoxine acid. ATыводится с мочой спустя 2-5
hours after suction.

Indications for use

Both the solution and the dragee are used as pathogenetic and
symptomatic means of neurological pathologies, in a complex
treatment of diseases and syndromes of the nervous system:

  • Neuralgia;
  • Neuritis, retrobulbar neuritis;
  • Paresis of the facial nerve;
  • Polyneuropathy, including alcoholic and diabetic, and
    also:

Pills

Injections

  • Myalgia;
  • Radicular syndromes;
  • Herpes zoster;
  • Systemic pathologies of the nervous system associated with laboratory
    доказанным дефицитом витаминов AT1 и AT6.
  • Ganglionites;
  • Neuropathy;
  • Plexopathy;
  • Night cramps of muscle tissue;
  • Neurological symptoms of osteochondrosis: lumboischialgia,
    radiculopathy, musculo-tonic syndromes.

Contraindications

General contraindications indicated in the instructions for use
Milgammas are:

  • decompensated heart failure
  • idiosyncrasy
  • childhood
  • pregnancy and breastfeeding.

Dosage

Pills Мильгаммы

They are usually prescribed for three times a day;
1 tablet at the reception. Be sure to wash down with a sufficient amount
water. AT инструкции по применению Мильгаммы композитум указан курс
treatment – 1 month.

Solution

Injections Мильгаммы назначают для внутримышечного введения глубоко в
the cloth.

  • ATыраженный болевой синдром, сопровождающий неврологические
    pathology: 2 ml daily course of 5-10 days.
  • Mild forms of the disease, relief of acute pain in the background
    the above treatment: 2 ml 2-3 times a week for 3
    weeks or go on oral dosage form
    (dragee)

When taking any form of Milgamma is recommended
weekly monitoring of therapy. When improving condition
It is recommended to immediately switch from injections to receiving pills.

Side effect

  • Dragee и раствор — Редко может развиваться тахикардия и аритмия.
    Rarely, allergic reactions in the form of urticaria, skin
    rashes, even less often severe reactions like anaphylactic shock,
    Quincke’s edema. Some patients note increased sweating,
    acne skin rash.
  • Solution — может наблюдаться спутанность сознания,
    dizziness, occasionally – spasms. AT отдельных случаях отмечается
    vomiting. Local reactions may also develop at the site of administration.
    injections in the form of irritation.

Overdose – possible development of reactions by type
effects are more pronounced.

special instructions

In the case of accidental intravenous administration of Milgamma should be provided
medical observation or hospitalization in the development of severe
symptoms. Information about the possibility of using the drug for
simultaneous work with complex mechanisms or driving cars
The instruction does not contain.

Drug interactions

  • Levodopa – reduced antiparkinsonian action
    medications;
  • Sulfites, iodites, carbonyls, carbonates, ammonium iron,
    phenobarbital, dextrose, riboflavin, disulfites, benzylpenicillin,
    tannin acid, copper – the destruction of thiamine in the composition
    Milgamma;
  • Norepinephrine and epinephrine, sulphonamides – enhanced action
    lidocaine in Milgamma heart;
  • With caution prescribed with simultaneous treatment with
    D-penicillamine or cycloserine (reduced effect
    last);
  • Соли тяжелых металлов – несовместимы с витамином AT12 в составе
    drug.

Cheap Milgamma analogues

ATитагамма 74-140 руб. Binavit 122-145 rub. Combined 140-230 rubles. Комплигам AT 260 руб.
Neyrobion 177-200 rub. Neuromultivitis from 153 rubles for 20 tablets. Neurobeks from 118 rubles for 30 tablets.  Тригамма 5 amp. 80-120 rubles

Автор: врач-гигиенист, эпидемиолог

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