Update: October 2018
Mexidol is in the group of commonly prescribed drugs in
neurological practice. Active ingredient of the drug –
ethyl methyl hydroxypyridine succinate:
- Prevents and reduces the harmful effects of free radicals
on tissue and cells
- Protects cell membranes from the action of various toxins
- Increases overall hypoxia resistance, has
- Mexidol is quite effective in treating various types.
hypoxia, as well as circulatory disorders in acute or chronic
- Mexidol therapy leads to improved memory, improved
cognitive function and learning ability.
- It has a good effect in the treatment of uncomplicated depression,
because it increases dopamine production.
- It is a drug of choice for the treatment of vegetative dystonia,
abstinence syndrome, atherosclerosis (see statins with high
cholesterol), drug addiction.
Mexidol increases resistance to the action of pathological external
factors and oxygen-dependent states such as stress,
conflicts, shock, insomnia, hypoxia and ischemia, head injuries
brain, mental and physical overload, brain disorders
hemodynamics, intoxication (ethanol, psychotropic stimulants and
others). Slows down the process of cellular aging.
Фармгруппа: Препараты для лечения заболеваний
nervous system – antihypoxants and antioxidants.
The composition of the drug
Mexidol is available in two medicinal formulas: solution in
vials intended for intravenous and intramuscular
routes of administration, and oral tablets.
Mexidol tablets, 125 mg
Mexidol solution, 5%
|125 mg Ethylmethylhydroxypyridine succinate||50 mg Ethylmethylhydroxypyridine succinate|
|Auxiliary components: sodium carboxymethylcellulose,
lactose monohydrate, magnesium stearate
|Auxiliary components: 1 mg of sodium metabisulphite, and
water d / and up to 1 ml
|Shell: titanium dioxide, opadry II white, alcohol
Release form, price
- Mexidol tablets: biconvex, round, with a shell
from white to white and cream color, 125 mg, No. 30, No. 50. Price:
Mexidol № 30 – 200-250 rubles, № 50 – 330-380 rubles.
- Mexidol solution: colorless or yellowish transparent
liquid in glass ampoules with volume 2 and 5 ml № 5, № 10, № 20, №
50 (for hospitals). Price: № 5 — 380-460 руб, № 10 — 380- 480
rub, № 20 – 1440-1500 rub.
According to the instructions for use Mexidol is characterized by
complex pharmacological action, has antioxidant,
adaptogenic, nootropic, membrane stabilizing,
cerebroprotective, anxiolytic, vegetotropic,
- Inhibits fat peroxidation, activates antioxidant
system, accelerates mitochondrial synthesis of energy, improves
cellular energy metabolism.
- Activates protein and nucleic acid synthesis inside
cells, accelerates the enzymatic reactions of the Krebs cycle and recycling
glucose, promotes the synthesis of ATP and its accumulation inside
- Restores cell membrane function and structure, modulates
membrane-bound enzymes, improves the interconnection of brain structures
and synoptic transmission.
- Improves cerebral hemodynamics, incl. microcirculation
positive effect on blood fluidity, limits ischemia
brain and stimulates reparative processes.
- Improves immune system function, suppresses adhesion
- Lowers low-density lipoprotein and cholesterol
promotes regression of atherosclerotic changes in
Indications for use
- Minor Atherosclerotic Cognitive Function Disorders
- Vegetative dystonia
- Anxiety disorders with neurosis
- Alcohol withdrawal syndrome
|Consequences of acute disorders of cerebral hemodynamics in phase
|Acute cerebral hemodynamic disorders|
|Easy TBI, effects of TBI||TBI, consequences after TBI|
|Encephalopathy (mixed, post-traumatic, etc.)||Encephalopathy|
|IHD (in the treatment complex)||Acute myocardial infarction (in the treatment complex)|
|Condition after acute antipsychotic intoxication||Acute antipsychotic intoxication|
|Asthenic conditions, prevention of somatic diseases in
conditions of extreme mental and physical stress
|Primary open-angle glaucoma (in the treatment complex)|
|Stress exposure factors||Acute necrotic inflammatory processes in
abdominal cavity (in the treatment complex)
Acute renal and hepatic failure, increased
sensitivity to active and auxiliary substances
In view of the insufficient study of the effect of the drug,
Mexidol tablets are not used to treat pregnant and lactating
women, as well as children.
It is prescribed with caution to patients with high and low
values of blood pressure and hypertension with crises.
|Is ingested in a single dose from 125 to 250 mg three times a
during the day
|Introduced intramuscularly or intravenously (jet injection 5-7
minutes or drip 40-60 drops in 1 minute). For
infusion Mexidol diluted in 0.9% NaCl solution.
|The initial dose is prescribed with 125 or 250 mg with a single dose.
or twice a day, gradually increasing to
|Acute cerebral hemodynamic disorders: 10-14 суток по 200-500
mg intravenous drip 2-4 times / day, the next 2
weeks: 200-250 mg intramuscularly twice or thrice a day.
|Treatment is stopped with a gradual decrease in the dose of the drug in
for 2 days.
|TBI and effects of TBI: 10-15 days intravenous drip
the introduction of 200-500 mg 2 to 4 times a day.
|The maximum daily dose of 800 mg.||Encephalopathy: 14 суток внутривенно струйным
or drip injections of 200-500 mg once or twice a day,
the next 2 weeks in / m at 100-250 mg / day.
|The duration of treatment from 5 days to 8 weeks.||Mild cognitive dysfunction and anxiety disorders: 14-30
days intramuscularly at a dosage of 100-300 mg / day.
|Repeated courses are recommended in spring and autumn periods.||Acute myocardial infarction: the first 5 days intravenously
100-150 ml for 30-90 minutes, the next 9 days – in / m. Introduction
Mexidol (in / in and / m) produce 3 times / day every 8 hours from
calculating a daily therapeutic dose of 6–9 mg / kg body weight. Maximum
single dose – 250 mg daily 800 mg.
|Open-angle glaucoma: 14 days intramuscularly at a dose of 100-300
мг/сут 1-3 раза в during the day.
|Alcohol withdrawal syndrome: 5-7 days intravenous
by drip or intramuscularly in a dose of 200-500 mg
twice or thrice a day.
|Acute antipsychotic intoxication: 7-14 дней внутривенно по
200-500 mg / day.
|Acute swollen pancreatitis: intravenous drip method and
внутримышечно в дозе 200-500 мг трижды в during the day.
Mild necrotic pancreatitis: intravenous
Moderate severity: intravenous drip route
Heavy course: 800 mg 2p / day, then 200-500 mg 2 times / day,
- Gastrointestinal tract: individual dyspeptic symptoms, in / in
Introduction – dry mouth, tickling and metallic taste.
- Other: allergic skin reactions, drowsiness.
Overdose: likely to develop drowsiness and sedation.
In patients with bronchial asthma with high sensitivity to
sulphites are likely to develop severe reactions. During the period of therapy
Mexidol should be careful if necessary.
driving vehicles and performing work requiring precise
It is combined with all drugs for the treatment
somatic pathologies. Potentiates the action of tranquilizers,
analgesic anticonvulsant and antiparkinsonian
Analogs of Mexidol
Mecipridol; Medomeksi; Neurox; Metostabil; Cerecardum;
Mexidant; Mexiprim; Mexicor; Mexicin; Armadin.
5ml 20amp. 830 rub.
30 tab. 200 rubles, 60 tabl 330 rubles, 10 amp. 2 ml.360 rub.
10 amp. 2 ml. 340 rub.
10 ml. 10 pieces. 290 rub.
Автор: врач-гигиенист, эпидемиолог