Longidase, candles, injections: instructions forapplication, indications, contraindications, side effects,dosage

Update: October 2018

Longidase is an effective enzyme preparation with
proteolytic, i.e. protein cleavage action as well
immunomodulatory, anti-inflammatory and antioxidant
activity. The drug has a long therapeutic
Effect.

Two active components in the composition of the drug – azoksimera bromide
and hyaluronidase, lead to the following positive effects:

  • improved tissue permeability;
  • trophic enhancement;
  • resorption of hematomas;
  • reduction of edema;
  • increase tissue elasticity;
  • the disappearance of adhesions and contractures;
  • increased joint mobility;
  • suppression of connective tissue growth in scars.

Longidase can bind heavy metals and neutralize
toxins. The drug does not cause carcinogenic, mutagenic,
toxic and embryotoxic action on the body and well
tolerated by patients – according to reviews, injections and Longidase candles do not give
unwanted reactions.

Фармгруппа: Препараты с протеолитической activity.

The composition of the drug, physico-chemical properties and price

The drug is produced in two dosage forms: suppositories
(method of administration rectally or vaginally) and lyophilisate for
obtain a solution of subcutaneous or intramuscular injection.

Suppositories

Lyophilisate

Main substance Longidase with hyaluronidase activity: 3000 IU Longidase with hyaluronidase activity of 1500 IU (ampoules and
bottles of 1500 IU) or 3000 IU ampoules and bottles of 3000 IU)
Excipients Cacao butter Mannitol 15 mg (vials and ampoules 1500 IU) or 20 mg (ampoules and
vials 3000 IU)
Physicochemical properties Candles elongated, yellowish, with a faint odor
cocoa butter. Marble coloring of the suppository is acceptable.
Porous hygroscopic mass having a white or white and yellow
Colour.
Packaging On 5 suppositories in contour cells, enclosed in cardboard
packs.
On 5 ampoules or bottles in cellular packings enclosed in
картонные packs.
Price

  • № 10: 1337-1662 rub.

  • Bottles No. 5: 1366-1824 rub.
  • Ampoules number 5: 1584-1600 rubles.

 pharmachologic effect

The drug has a prolonged enzymatic
proteolytic action. Prolongation of action occurs
due to covalent longidase binding to high molecular weight,
active carrier (derived N-oxide
poly-1,4-ethylene piperazine), which possesses pharmacological
activity.

Covalent bond ensures enzyme resistance to
destructive reactions and the action of inhibitors, as well as simultaneous
local presence of carrier and hydrolytic enzyme,
binding enzyme inhibitors and collagen synthesis activators
(ions of copper, iron, heparin). That is why Longidase is capable
depolymerise the connective tissue matrix in
fibro-granulomatous structures, as well as suppress regulatory
the reaction necessary to synthesize the structural units
connective tissue.

Glycosaminoglycans, such as chondroitin, hyaluronic acid,
chondroitin-4 and -6-sulphate are specific substrates
hyaluronidase testicular. They form the basis
connective tissue matrix. As a result of depolymerization under
the influence of hyaluronidase substrates lose their properties, such as
ability to bind water, viscosity, etc. Also difficult
the conversion of collagen protein into fiber is enhanced
permeability of tissue barriers, improves the movement of fluid between
cells and ultimately improves the elasticity of the connective
tissue.

Longidase helps to reduce the manifestations of the acute phase
inflammation, affects the synthesis of inflammatory mediators,
increases infectious resistance and increases tension
humoral immunity.

Pharmacokinetics

When parenteral route of administration quickly enters the system
blood flow, reaching maximum concentration in 20-25 minutes.
It is quickly distributed through tissues, penetrates into all organs and
structures, including the brain, but not cumulated.

With rectal and vaginal administration also quickly falls into
blood flow, reaching maximum concentration after 1 h.
The bioavailability of suppositories is 70%. Excreted by the kidneys
(elimination half-life makes 42-84 h). Metabolized to
low molecular weight oligomers.

Indications for use

Used in the treatment of children from 12 years and adults
with pathologies occurring with connective tissue hyperplasia.
It is also prescribed to improve the bioavailability of diagnostic and
therapeutic drugs.

Lyophilisate

Suppositories

Pulmonology, gynecology and urology during development
interstitial inflammatory response:

  • chronic cystitis;
  • alveolitis, tuberculosis, pneumofibrosis;
  • adhesions in the pelvis;
  • infertility (tubo-peritoneal).

Orthopedics, surgery, cosmetology:

  • scars after traumatic injuries, pyoderma, burns,
    operations;
  • wounds are nonhealing;
  • arthritis, joint contractures, hematomas;
  • spikes.

Dermatovenereology:

  • limited type scleroderma localization.
Urology:

  • chronic prostatitis;
  • strictures of the ureters and urethra;
  • interstitial cystitis;
  • Peyronie’s disease;
  • benign prostatic hyperplasia in the initial stage;
  • prophylaxis of scars and strictures after surgical procedures
    on the bladder, urethra, ureters.

Gynecology:

  • prevention and therapy of adhesive processes of the small pelvis
    pathologies of the internal genital organs of inflammatory nature and
    chronic course, as well as after gynecological manipulations and
    operations;
  • intrauterine synechia;
  • chronic endomyometritis;
  • infertility tubal-peritoneal.

Dermatovenereology:

  • prevention of fibrous formations after STIs;
  • limited scleroderma.

Surgery:

  • prevention and treatment of adhesions after organ surgery
    abdominal cavity;
  • wounds with a long healing period.

Contraindications

  • Malignant tumors;
  • Pregnancy;
  • Children’s age up to 12 years;
  • Hypersensitivity to Longidase and other drugs with
    гиалуронидазной activity.

With a lack of renal function and pulmonary bleeding earlier
– Appoint no more than 1 time per week.

Lyophilisate

The method of administration and dosing is carried out individually,
based on the severity, the clinic of pathology and the age of the person.

According to the instructions for use Longidase injections indicated that
Requires preliminary preparation of the solution. Bottle Contents
or ampoules are dissolved in one and a half to two ml of 0.25% or 0.5% p-ra
procaine or in 0.9% NaCl solution, water for injection with
procaine intolerance. The solution can not be stored, therefore introduced
immediately cooking field.

Injected subcutaneously near the affected tissue or / m in a dosage of 3000
IU In total, 5-15 injections are prescribed with a time interval between
every 3-10 days. Repeated course – in 2-3 months.

With pathologies with severe chronic productive process
nature of the connective tissue after treatment is assigned
maintenance therapy of 3000 IU in 10-14 days.

To improve the bioavailability of other drugs: 1500 IU once
after 3 days, the total number of injections should not exceed 10.

Recommended treatment regimens

  • Pathology of the respiratory system: 3000 IU once in 3-5 days –
    total 10 intramuscular injections. Maintenance treatment: 3000 each
    IU once in 10-14 days (up to 12 months).
  • Pathology of the pelvic organs: 3000 IU once every 3-5
    days course of 5-15 intramuscular injections.
  • Scleroderma: 3000-4500 IU once in 3 days in a course of 5-15
    intramuscular injection.
  • Scars: 3000 IU inside the rumen in a dose of one to two times a week 5-10
    injection or 3000 IU once every 3-5 days – only 10
    intramuscular injection.
  • Non-scarring wounds: 1500-3000 IU once in 5 days
    курсом 5-7 intramuscular injection.
  • Arthritis, contractures, hematomas: 3000 IU once or twice a week
    7-15 intramuscular injection.
  • Adhesive disease: 3000 IU once in 3-5 days 7-15
    intramuscular injection.

Candles Longidase: instructions for use

Appointed for rectal or intravaginal administration.
once a day for the night course of 10-20 candles. For rectal
administration is recommended to introduce a candle after emptying the bowel.
With intravaginal administration – injected in the supine position.

Recommended regimens

  • Urology: по 1 свече через 1 день 10 введений, затем через 2-3
    days – 10 more introductions.
  • Gynecology: по 1 свече через двое суток — 10 введений.
  • Dermatovenereology: по 1 свече через один-два дня. On course
    10-15 candles.
  • Surgery: по 1 свече через два-три дня. On course 10 свечей.
  • Pulmonology and phthisiology: 1 candle in two to four days. On
    course of 10-20 suppositories. Supportive treatment – 1 candle
    once a week for 3-4 months

Side effects

  • Local: pain at the injection site, rarely – hyperemia and
    skin swelling. When using candles occasionally itching and
    puffiness at the injection site.
  • Allergic reactions are rarely possible.
  • All side effects pass after 48-72 h.

Drug interactions

Reduced Longidase activity while treating
estrogens, salicylates, cortisone, ACTH, antihistamine drugs in
high doses. Consideration should be given to increasing the bioavailability of the second
drug at simultaneous use with Longidaza.

special instructions

Longidase should not be injected into an acute or infectious area.
lesions. In the treatment of acute foci of infection at the same time
prescribe antimicrobial agents.

With the development of any allergic reaction, the drug is canceled.

Переdosage

Such cases are not recorded.

Analogs:

Lidaza (10 amp. 200 rub), Lidaza – M and
Ronidaza.

Автор: врач-гигиенист, эпидемиолог

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