Update: December 2018
When a doctor prescribes a drug like Biseptol, especially
children (suspension), many are interested in the question – is Biseptol
antibiotic or not? Means such as nitroxoline, streptocide,
Phthalazole, Biseptol, Metronidazole, etc. are not antibiotics –
these are antimicrobials. Differences them from true
- mechanism of action on pathogens
- general effect on the body
Antibiotics are semi-synthetic or
natural origin, have antimicrobial action, and
Biseptol is a fully synthesized drug that relates to
pharmacological group of sulfonamides, which traditionally have been
It is called antibacterial chemotherapy drugs.
Antibiotics kill bacteria or inhibit their growth and reproduction.
Sulfonamides are incorporated into the structure of microorganisms instead of
para-aminobenzoic acid, and disrupt metabolic processes,
vital activity, growth and reproduction of bacteria. In spite of
similarity of action mechanisms, sulfonamides (biseptol)
antibiotics are not. This is another antimicrobial group.
Sulfonamides are the first systemic antimicrobial
means. Their use for 65 years has provoked
the emergence of a mass of microbial strains that have become resistant
(resistant) to them. It was possible to increase the sensitivity of bacteria when
creating combination drugs by combining these antimicrobial
drugs with trimethoprim – Co-trimoxazole (analogs Biseptol –
suspension price 110 rubles. Table 30-70 rubles, Bactrim – price 170 rubles,
Bi-septin, Brifeseptol, Dvaseptol, Duo-septol), as well as this
The group includes Sulfalen, Sulfadimethoxin, Sulfaethidol. AT
In some cases, when an infectious disease occurs,
pathogens that remain sensitive to drugs of this
groups, is still prescribed Biseptol, especially for infections
urinary tract and to prevent development on the background of AIDS
Biseptol and other sulfonamides have not been found in recent years.
widespread use in medical practice. Appearance
modern broad-spectrum antibiotics, active
the use of fluoroquinolones has led to the use of
sulfonamides significantly decreased.
Indications and contraindications to the use of Biseptol
Biseptol and its analogues are indicated for diseases when
The sensitivity of pathogenic microorganisms to
Co-trimoxazole. Sulfonamides inhibit the growth of some of the simplest
– toxoplasmosis, malaria, as well as gram-positive and
Gram-negative bacteria, chlamydia, therefore, are used for:
- ENT diseases – otitis in children, sinusitis (see
antibiotics for sinus)
- Infectious diseases of the genitourinary system, soft chancre,
urethritis, pyelonephritis, cystitis (all tablets for cystitis), prostatitis
(treatment of prostatitis with antibiotics), salpingoophoritis, gonorrhea
- Respiratory diseases – Pneumonia, acute
и хронический бронхит, абсцесс легкого
- Infections of soft tissues and skin – pyoderma, furunculosis
- Toxoplasmosis – in complex therapy, osteomyelitis, acute
- Infectious diseases of the digestive tract – travelers’ diarrhea,
dysentery (symptoms of dysentery), typhoid fever, cholera, paratyphoid fever
Biseptol and its analogues are contraindicated in case of:
- Severe renal and hepatic failure
- Hyperbilirubinemia in children
- Simultaneous use with dofetilide
- Pregnancy and lactation
- Children’s age – for suspensions up to 2 months, for tablets,
capsules – up to 3 years
- Severe blood disorders – anemia with folic deficiency
кислоты, апластическая анемия, лейкопения, AT12-дефицитная анемия,
megaloblastic anemia, agranulocytosis
- Hypersensitivity to trimethoprim, sulfonamides and
- Deficiency of glucose-6-phosphate dehydrogenase
- With caution to receive in bronchial asthma,
thyroid diseases, with folic acid deficiency.
Side effects of Biseptol
- Syndromes appear on the skin (urticaria, rash), which means
liver functions are affected, and hepatitis can develop,
- Development of aplastic anemia
- Нарушение функции почек, полиурия, гематурия, повышение
- Повышение температуры тела, аллергический кашель,
allergic myocarditis, bronchospasm.
- ATозможна анафилаксия, анемия, тромбоцитопения.
- Headache, tremor, dizziness, rarely aseptic
meningitis, peripheral neuritis.
- Vomiting, nausea, pancreatitis, gastritis, stomatitis.
- Depression, apathy.
- Myalgia, arthralgia.
Myths about Biseptol and other sulfonamides
1 Миф — Сульфаниламиды практически безвредны и у нtheir нет
Self-treatment with Biseptolum and other sulfonamides is completely
is unacceptable. They have a lot of side effects, first
queue have a toxic effect on the kidneys and liver, dangerous
for pregnant women, can cause allergic reactions, aplastic
anemia, etc. However, the risk of developing intestinal dysbiosis with their
use is significantly lower than with antibiotics.
Biseptol in Europe and the USA is prohibited for children under 12
Co-trimaxazole is a side effect drug
life-threatening. Danish Medical Academy, found that
Biseptol (Co-trimaxaxol) has a depressing effect on blood formation,
leading to a state where the bone marrow does not produce vital
important white blood cells – granulocytes, i.e. to aplastic anemia. it
severe violations of hemopoiesis, about which patients without treatment
die in a few months. Aplastic anemia provokes
complete bone marrow atrophy and for the seriousness of the disease she
stands on par with blood cancer.
2 Myth – Biseptol reduces the risk of complications of influenza and
Biseptol does not create prevention of complications of influenza, as they say
many do not apply to the treatment of influenza and viral diseases
(see Flu symptoms in adults, how to recover from
3 Миф — Сульфаниламиды очень вредны, поэтому their надо
use 2-3 days until it becomes easier, and no longer worth
poison the body
Resistance to sulfonamides develops fairly quickly.
бактерий и прерывать назначенный врачом курс в терапевтическtheir
doses not acceptable. it чревато развитием устойчивости в дальнейшем
to sulfonamides (see how to take antibiotics correctly).
4 Myth – Biseptol tablets, capsules can not drink water,
and chew or swallow whole
Since the drugs in this group can cause a violation
функции почек, при their использовании следует принимать обильное
drink better alkaline. Taking Biseptol may in some cases
plug the urinary tract with insoluble crystals,
especially in acidic urine, so you should take a pill and
consume large amounts of fluid.