Update: October 2018 Lasolvan Cough Syrup is a popular
mucolytic drug that is used in pediatrics and for
treatment of adults. The most commonly prescribed syrup is with a dry cough,
when sputum excretion is difficult. Also Lasolvan is presented in
dosage forms oral tablets and lozenges and solution,
which is used for inhalation.
The active substance dilutes the bronchopulmonary secret and
contributes to its natural discharge. The drug is indicated for
treatment of various respiratory diseases with a clinic with
sputum difficult to separate. When it comes to children, the main
indications for therapy are: bronchitis, tracheitis, bronchial
asthma, pneumonia, cystic fibrosis. Adult drug
prescribed for bronchiectasis, COPD (chronic
obstructive pulmonary disease).
The drug belongs to the group of adjuvant therapy.
Farmgroup: Expectorant and mucolytic drug.
Composition, physico-chemical properties, price
Lasolvan is produced in the form of two syrups for the internal
use, one of which (30 mg / 5 ml) is used in adults
patients and children from 6 years. In the instructions for use Lasolvana
syrup for children with a dose of 15 mg / 5 ml indicated that it can
assigned to children from birth and adults.
|Syrup 30 mg/5 мл||Children’s syrup 15 mg / 5 ml|
|Main substance||Ambroxol hydrochloride|
|30 mg||15 mg|
|Excipients||8.5 mg benzoic acid, 750 mg glycerol 85%, gietellose 10
mg, 5 mg of acesulfame potassium, 1750 mg of sorbitol liquid, 12 mg
strawberry cream flavor, 3 mg vanilla flavor,
3031.5 mg of water.
|8.5 mg benzoic acid, 750 mg glycerol 85%, gietellose 10
mg, 5 mg of potassium acesulfame, 1750 mg of sorbitol liquid, 11 mg
flavor berry forest, 3047.5 mg of water.
|Physicochemical properties||Transparent or almost transparent syrup that has no color,
slightly viscous, with the aroma of strawberries.
|Transparent or almost transparent syrup that has no color,
slightly viscous, with the scent of wild berries.
|Packaging||Syrup по 100 и 200 мл во флаконах из затемненного стекла со
a cup measured, in packs cardboard.
Price сиропа Лазолвана:
|Main substance||Ambroxol hydrochloride|
|30 mg||15 mg|
|Excipients||171 mg of lactose monohydrate, 36 mg of corn starch
dried, 1.8 mg of colloidal silica, 1.2 mg of stearate
850 mg of acacia gum, 370.4 mg of sorbitol, 614.8 mg of karyon 83,
leaf eucalyptus leaf oil, 1.8 mg of sodium saccharinate,
|Physicochemical properties||White or yellowish round-shaped tablets, flat, having
bevelled edges, with a riser dividing on one side and
engraved “67C” and the symbol of the manufacturer to another
to the side.
|Light brown lozenges, round, with peppery flavor
|Packaging||10 tab. in blisters, 2 or 5 blisters in a carton
|10 pastes each. in a blister. In a cardboard bundle of 1, 2 and 4
|Price||№ 20 – 160-200 rubles.||№ 20 – 160-180 rubles.|
In multiple medical studies it was found that
Ambroxol increases the secretory function of the respiratory tract.
The substance accelerates the production of surfactant and activates the ciliary
These effects cause an increase in current and movement of mucus along
respiratory tract. Thus, sputum transport is improved and
cough is much easier.
It is noted that with prolonged treatment with Lasolvan (2 months or more)
in patients with COPD, the number of exacerbations decreased, and
shortened the duration of the acute period and the duration
For all forms of the drug immediate release characteristic
almost complete, fast absorption with direct dependence on
therapeutic dose in the therapeutic concentration range.
With internal reception the maximum content of ambroxol in
blood plasma is noted in 1.5-2 hours. Upon reaching
therapeutic concentration of plasma protein binding
reaches a maximum of 90%. Ambroxol transport from blood to tissue
with internal reception occurs quickly. Highest concentrations
Ambroxol is just observed in the lung tissue.
About 30% of the administered dose of the drug is affected.
primary transport by the liver. The predominant isoform host
participation in the conversion of ambroxol to dibromantranilic acid,
is CYP3A4. The rest of ambroxol is exposed
metabolism in the liver, mainly by glucuronidation and partial
digestion to the metabolite of dibromantranilic acid and other
T 1/2 is 10 hours. Overall clearance varies to the limit.
660 ml / min, at the same time about 83% of renal clearance drops out
Clinically significant influence of age and sex characteristics
on the pharmacokinetics of ambroxol is not detected, so when choosing
dosage data signs not taken into account.
The drug is indicated for болезнях органов дыхания острого и
chronic course, which are accompanied by the release of viscous
- acute and chronic bronchitis;
- bronchial asthma;
- Pregnancy (1 trimester);
- Дети до 6 лет (сироп 30 mg/5 мл и пастилки) и до 18 лет
- Fructose intolerance;
- Individual hypersensitivity to ambroxol and others
- Lactose intolerance, lactase enzyme deficiency,
glucose-galactose malabsorption (for l / f tablets).
Pregnant women in the 2nd and 3rd trimester, people with hepatic or renal
insufficiency of the drug is prescribed with caution.
Ambroxol is proven to penetrate the placental barrier. Wherein
negative (direct or indirect) effects on pregnancy,
intrauterine development of the fetus is not installed. However,
the drug is prescribed with caution and in case the benefit to
females outweigh potential risks with respect to fetus.
Ambroxol is also excreted with breast milk, therefore not
recommend the use of the drug in the lactation period.
All described forms are intended for oral administration, outside
depending on the meal. Pills запивают водой. Pastilles
dissolve in the mouth until dissolved.
Syrup 15 mg/5 мл:
- children from birth to 2 liters: 2.5 ml twice a day;
- children 2-6 liters: 2.5 ml three times a day;
- children 6-12 liters: 5 ml three to two times a day;
- children from 12 liters, adults: 10 ml three times a day.
Syrup 30 mg/5 мл:
- children 6-12 liters: 2.5 ml two or three times a day;
- children from 12 liters, adults: 5 ml three times a day.
1 tab. (30 mg) трехкратно в сут. Dose may increase to 2
tab. (60 mg) twice a day.
- children 6-12 liters: 1 pastille two or three times a day;
- children from 12 l, adults: 2 lozenges three times a day.
If symptoms persist for more than 4-5 days during treatment
Lasolvan, you should see a doctor.
- Digestive system: often nausea, decreased sensitivity
in the pharynx and oral cavity, less often – vomiting, dyspepsia, diarrhea, pain in
epigastric, dry mouth. Rarely, dryness may occur.
- Nervous system: often a violation of taste.
- Allergic reactions: rarely possible phenomena such as
urticaria, rash, pruritus, angioedema and others
If therapeutic doses are exceeded, nausea may develop,
dyspepsia, vomiting and diarrhea. Symptomatic treatment.
Sorbitol, which is part of the pastilles and syrup, is capable of
have a mild laxative effect.
Ambroxol does not affect the central nervous system, so the use of
Lazrolvana does not limit the ability to control mechanisms
by car, etc.
Any significant effect when interacting with Lasolvan
other drugs are not marked. With conscientious use with
amoxicillin, cefuroxime and erythromycin marked increase
therapeutic effect of the latter, since it improves
penetration of active substances in the bronchopulmonary secretion.
Lasolvan can not be combined with antitussives,
that reduce sputum excretion – an effect will be observed,
reverse to the desired.
Analogs сиропа Лазолван: Амброгексал, Ампробене, Амброксол,
Ambrosol, Flavamed, Halixol. Bronchorus.
Автор: врач-гигиенист, эпидемиолог