Instructions for use cycloferon intablets, solution for injection

Update: October 2018 Cycloferon – Popular Antiviral
domestically boosted medicinal product
body resistance. It is a high molecular activator
formation of interferon and has the broadest spectrum
pharmacological activity.

High therapeutic drug activity
due to the spectrum of biological action. Effective in therapy
viral diseases, including flu, are also
Cycloferon is prescribed for some bacterial
infections like immunostimulant. Traditionally used when
immunodeficiencies of varying severity, including
HIV infection. Characterized by anti-carcinogenic effect and
inhibits the development of autoimmune reactions, which further expands
therapeutic range of the drug.

Cycloferon has been on the pharmaceutical market for more than 20 years
affordable price in its segment and is the drug of choice when
immunodeficiencies, as well as viral diseases.

Composition, physico-chemical properties, price

The drug is produced in 3 dosage forms: liniment for
local topical tablets, oral and
parenteral solution.

Cycloferon tablets / 150 mg A solution of 12.5% ​​in ampoules Liniment 5%
Main substance Meglumine acridone acetate – 150 mg in 1 tablet Meglumine Acridone Acetate – 125 mg in 1 ml Meglumine acridone acetate – 50 mg in 1 ml
Auxiliary components Povidone – 7.93 mg, propylene glycol – 1.79 mg, calcium stearate
– 3.07 mg, polysorbate – 0.27 mg, methacrylic acid and copolymer
ethyl acrylate – 23.21 mg, hypromellose – 2.73 mg
Water d / and up to a volume of 1 ml Benzalkoniya chloride – 0.1 mg, up to 1 ml of 1,2-propylene glycol
Physico-chemical properties Yellow biconvex tablets, round, covered
Clear, yellow solution Yellow clear liquid with a specific smell
Packaging 10 and 20 tables. in cellular packages, packs of cardboard. On 2 ml in ampoules from brown or transparent glass,
placed in the cellular packaging and cardboard packs.
On 5 and 30 ml in tubes, a dosage of 30 ml – with vaginal
applicators. In cartons.
Appearance циклоферон в таблетках циклоферон в ампулах циклоферон в тубах
Price № 10: 145-190 rub. № 5: 300-350 rubles. 30 ml: 380-400 rubles.

pharmachologic effect

Cycloferon has 2 pronounced effects: antiviral and
immunomodulatory, as well as anti-inflammatory,
antiproliferative (overwhelmingly excessive cell growth) and
antitumor effect. In the body meglumine acridone
potentiates synthesis and accumulation in organs and tissues
significant interferon titers α and β. The greatest
interferon content is noted in structures rich in lymphoid
tissue: spleen, lungs, intestinal mucosa, liver.

Cycloferon activates bone marrow stem cells,
ensures the formation of granulocytes. Normalizes the ratio
T-suppressors that suppress the formation of antigens and T-helpers,
enhancing the adaptive immune response. Activates killer cells and
T lymphocytes. This effect is especially important in immunodeficiencies.
different nature, because it leads to the correction of the immune
status. Penetrates into the brain tissue.

Thus, cycloferon:

  1. leads to marked improvement with common viral
    diseases like flu, herpes, enterovirus infection, and with less
    common pathologies: tick-borne encephalitis, hepatitis,
    cytomegalovirus and papillomatous infections;
  2. normalizes the immune status of HIV-infected;
  3. has antimicrobial and anti-Chlamydia action;
  4. prevents the onset of tumor processes due to
    antimetastatic and anticarcinogenic effects;
  5. suppresses autoimmune reactions, thereby reducing the severity
    pain and inflammation in rheumatic diseases and
    systemic pathologies of connective tissue;
  6. causes an improved balance of immunity when applied topically
    characterized by antiproliferative action and rapid elimination


After oral administration in 2-3 hours reaches maximum
plasma concentration. Gradually drug concentration
decreases and in a day cycloferon is found in the body in
residual quantity.

The half-life is 4-5 hours. At therapeutic dosages
cumulation of meglumine acridone acetate is not observed.


Tablets are prescribed in complex therapy in adults with:

  • flu and colds;
  • herpes;
  • OCI viral etiology;
  • neuroinfections, including tick-borne borreliosis and encephalitis,
    serous meningitis;
  • secondary immunodeficiency amid chronic infections
    caused by fungi and bacteria;
  • hepatitis C and B (chronic);
  • HIV infection in stage 2A-3B;

In children, cycloferon tablets are used as part of a complex
therapy for:

  • infections of herpetic etiology;
  • hepatitis C and B (both acute and chronic);
  • HIV infection in stage 2A-3B;
  • viral intestinal infections;
  • Acute respiratory infections and flu, as well as to prevent them.

The solution, as a drug of complex therapy, is shown
for treatment adult patients with the following conditions:

  • HIV infection in stage 2A-3B;
  • hepatitis C, D, A, B;
  • systemic diseases of connective tissue and diseases
    rheumatic diseases (rheumatoid arthritis, SLE);
  • neuroinfections, including with tick-borne borreliosis and encephalitis,
    serous meningitis;
  • infections caused by cytomegalovirus and herpes virus;
  • secondary immunodeficiency due to fungal and bacterial
    acute and chronic infections;
  • chlamydial infections;
  • pathologies of the joints (degenerative-dystrophic), incl. at
    deforming osteoarthritis.

У детей от 4 лет парентеральное atменение циклоферона показано

  • viral hepatitis C, A, D, GP, and B;
  • HIV infection (stage 2A-3B);
  • herpes infection.

Liniment cycloferon is a component of complex therapy and
atменяется местно у взрослых at:

  • herpes infection;
  • non-specific vaginosis and bacterial vagitis;
  • specific urethritis (gonorrheal, candidal, chlamydial,
    трихомонадном), баланопоститах, а также at неспецифических


  1. Decompensated liver cirrhosis – for pills and
  2. Hypersensitivity to the components of all drugs
  3. Children’s age up to 4 years (solution and tablets) and up to 18 years

Многих интересует, можно ли циклоферон at беременности и
lactation. The answer is unequivocal – all forms of the drug

special instructions

С осторожностью atменяется at эрозиях, гастритах, язвах
stomach / duodenum, duodenitis in the acute stage, as well as
at сильных аллергических реакциях.

Treatment раствором и таблетками at дисфункции щитовидки должно
conducted with the participation and control of the endocrinologist.

Does not slow down the reaction rate.

Инструкция по atменению циклоферона

Tablets for adults

Препарат atнимают однократно/сут, за полчаса до еды, не
chopping and drinking water. The dose depends on the disease and

  • Herpetic infection. At a dose of 2-4 table. according to the scheme: on 1st, 2nd,
    4th, 6th, 8th, 11th, 14th, 17th, 20th and 23rd days is the basic scheme
    suitable for most pathologies. For course treatment – 20-40
    tab. Начинают лечение at обострении заболевания;
  • ARI and flu. Взрослые по 2-4 tab. однократно/сут, 10-20 tab.
    for the course with the first symptoms. With severe flu single dose
    увеличивается до 6 tab. Prescribe and other drugs for
    symptomatic treatment (antipyretic and others);
  • Хронические гепатиты С и В. По 4 tab. according to the basic scheme, then
    – по 4 tab. once in 3-5 days about 3.5 months. On course
    необходимо 100-150 tab. When treating hepatitis C or mixed infections
    repeated courses are prescribed, in combination with other antiviral and
  • Intestinal infections (as a component of complex treatment): 2 each
    tab. на atем по базовой схеме до 8го дня, а с 11го — по 4
  • Neuroinfection. В дозе по 4 tab. on the basic scheme, then – on 4
    tab. in 5 days. The course of treatment is 2.5 months;
  • HIV infection. В дозе по 4 tab. according to the basic scheme, then в такой
    the same dose 1 time in 3-5 days for 2.5 months. 2-3 weeks course
    повторяют (на курс уходит 100-150 tab.);
  • Immunodeficiency. По 2 tab. according to the basic scheme.

Как atнимать циклоферон в детском возрасте

Препарат atнимают once per day., за полчаса до еды, запивая

  • Дети 4-6 лет: на atем по 1 tab.;
  • Дети 7-11 лет: на atем по 2 tab.;
  • Дети с 12 лет: на atем по 3 tab.

The treatment regimen depends on the pathology:

  • Acute viral hepatitis C, B: recommended dose by age
    двукратно через 1 день, затем переходят на трехразовый atем через
    48 ч, а далее – 5 atемов ч/з 72 ч;
  • Chronic viral hepatitis C and B: in recommended doses for
    age after 48 h, at the rate of 50-150 tabl;
  • HIV infection: age dose on 1, 2, 4, 6, 8, 11, 14, 17, 20
    days, then, according to the maintenance scheme, once every 3-5 days, about 5
    mon .;
  • Herpetic infection: 1, 2, 4, 6, 8, 11, 14 days – in
    age dose, then – based on the severity of the disease;
  • Кишечные инфекции: once per day. in the age dose of 1, 2,
    4, 6, 8, 11 days (6-18 tablets per course);
  • Influenza and acute respiratory infections: in age doses with a daily interval, 5-9
    atемов циклоферона на курс лечения;
  • Во время неблагоatятной ситуации по гриппу и другим ОРВИ для
    их профилактики: возрастная доза, которая atнимается на 1, 2, 4,
    6, 8 day, then another 5 times after 72 hours. Preventive course:
    10-30 tablets.

Схема atменения инъекций циклоферона у взрослых

Раствор вводят в/в или в/м once per day. according to the basic scheme:
on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23, 26, 29. The dose depends on

  • Viral hepatitis B, A, D, C. Single dose – 250-500 mg, per
    course total total dose of 2.5-5 grams. Total prescribed 10 injections,
    after 2 weeks the course is repeated;
  • Herpes and cytomegalovirus-associated infections: 10
    250 mg injections (total dose for a course of 2.5 grams). Most effective
    работает at лечении в самом начале обострения;
  • Neuroinfection. 12 injections in a dose of 250-500 mg. Treatment
    combined with etiotropic therapy. Total dose: 3-6 g.
    Repeated treatment is allowed;
  • HIV infection. Single dose – 500 mg, injected into / m 10 injections
    basic scheme. Supportive treatment that is prescribed after
    course: 500 mg once per 5 days for 2.5 months. After 30 days
    after the end – a repeated therapeutic course;
  • Chlamydia infections. 250 mg, 10 shots per course. Repeat
    treatment is carried out in 2 weeks. after the course. In this
    It is recommended that cycloferon be used with
  • Immunodeficiency states. 250 mg intramuscularly, 10
    injection. After 6-12 months Recommended re-course;
  • Systemic pathology of connective tissue and rheumatic
    diseases. 5 injections for 4 courses (in 10-14 days), in
    a single dose of 250 mg. Repeated courses are prescribed by a doctor;
  • Diseases of the musculoskeletal system
    degenerative-dystrophic nature. 250 mg – 2 courses of 5
    injections, with an interval of 10-14 days;

The scheme of cycloferon injection in children

The dose of cycloferon solution is calculated individually: 6-10
mg / kg body weight of the child. Enter intramuscularly or intravenously
once per day.

  • Acute hepatitis B, C, A, GP, D and mixed forms: dose, based on
    body mass, which is administered to 1, 2, 4, 6, 8, 10, 12, 14, 16, 18,
    20, 22, 24, 26, 28 days. With prolonged infection after 14 days
    repeat in the same way;
  • Chronic hepatitis C, B, GP, D. Dose by body weight, which
    enter on 1, 2, 4, 6, 8, 10, 12, 14, 16, 18th day, further
    a maintenance regimen is prescribed for 3 months 1 injection after 3
  • HIV infection. Enter the scheme of treatment of chronic hepatitis
    further: supporting scheme once in 5 days 3 months;
  • Herpetic infection. The weight calculated dose is administered at 1,
    2, 4, 6, 8, 11, 14, 17, 20, 23-day, after to maintain the effect:
    1 injection after 5 days.

Cycloferon regimen – local application

  • Herpetic infection. Liniment is applied to the affected area.
    тонким слоем, once per day., в течение 5 дней. With genital
    herpes make daily intraurethral or intravaginal
    instillation of 5 ml liniment (1 bottle) 1 time per day. 10-15 days.
    Liniment can be combined with other common and local
    antiherpetic agents;
  • Candida, non-specific urethritis. Do instillations 5-10
    ml of liniment (volume 1-2 bottles) in the urethra. The dose varies from
    severity of injury.

    • with the development of inflammation in the anterior urethra in men
      the cannula of the syringe with liniment is immersed in the external opening of the channel,
      then gently squeeze the hole for 1.5-3 minutes. Instillation
      the solution after a while stands out by gravity. Urinate
      need in half an hour (otherwise mucosal edema may develop).
    • with the defeat of the seminal glands or posterior urethra
      conduct intraurethral lintilization instillation with
      urethral catheter in 5-10 ml for 10-14 days in a row, once in
    • in the treatment of specific urethritis, it is imperative to use
      antibacterial agents that are susceptible to pathogenic
  • Candida and nonspecific colpitis, bacterial vaginosis,
    endocervicitis. Assign instillation liniment in the vagina 5-10
    мл ежедневно, 10-15 days. In order that the liniment did not follow,
    the vagina should be tamped with a small, sterile
    swab for 2-3 hours.
  • In the diagnosis of combined intraurethral and
    intravaginal infections should be applied instillation and in
    влагалище, и в уретру по 5 мл 10-15 days. Introduction is allowed.
    impregnated sterile tampons.

Liniment is combined with vaginal forms of drugs
(suppositories, tablets), therefore it can be used in combination with
chronic female genital pathology.

The above treatment regimens are basic and may
vary individually.

Side effects

Possible manifestation of general and local reactions

Drug interactions

The drug is 100% compatible with other drugs that
traditionally used in the treatment of these diseases, including
interferons, chemotherapeutic and symptomatic agents.
The enhancement of the effects of nucleoside analogs and interferons at
combined with cycloferon.

One of the positive effects of cycloferon is to reduce
the severity of side effects of interferon therapy and


Analogues of the composition is not currently registered.

Автор: врач-гигиенист, эпидемиолог

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