Immunoglobulin E: elevated, normal in children andadults

Update: October 2018

Immunoglobulins E (also called “reactants”) are such proteins
which are responsible for the development of allergic reactions type I or
PPHT (immediate type hypersensitivity).

Unbound (i.e., not attached to a squirrel or
another molecule) in the blood plasma, immunoglobulin E is located in the small
quantity. Most of it is attached to the cell walls,
which are “responsible” for the development of allergies. These are basophils and fat.
cells

Repeatedly in contact with a familiar allergen antigen
binds to the antibody in the membranes of mast cells and basophils
�“Open the gate”, from where “exit” and enter the blood granules with
biologically active substances: serotonin, histamine,
heparin, leukotrienes. This is how anaphylactic develops.
reaction.

In addition, he plays an important role in the development of protective
immunity, aimed at worms (worms).

The content of IgE in the blood is hundreds of times less than the main class
IgG antibodies. Most of the IgE molecules are in the tissues (lungs,
skin) and not in the blood. In contact with skin, hair, inhalation
light pollen, dietary protein intake of these antibodies
involved in the development of allergic reactions. That is the level of IgE
повышается у детей и adults с аллергическими заболеваниями.

The result of this analysis is not a basis for
establishing the diagnosis, or for its removal, it is one of the markers
allergic condition, if it is elevated, then you will need
additional examination of the patient.

Norm

Norm иммуноглобулина Е у детей различается в зависимости от
age Age fluctuations of its content in the blood are presented
in the table of the norm.

Age Ig E level, Units / ml
1-3 m 0-2
3-6 m 3-10
1 year 8-20
5 years 10-50
15 years 15-60
Adults 20-100

Norm иммуноглобулина Е у adults составляет 0 – 100 Ед/мл.

If the laboratory uses international units (IU / ml), then
the norms will differ from the above, in an adult they will be in
limits from 3 – 423.

Therefore, the results should be compared with the figures indicated on
form of a specific laboratory.

Age The level of IgE in the blood, IU / ml, to
0 to 5 months 14
6 to 11 months 35
from 1 to 2 years 98
3 years 200
from 4 to 6 years 300
from 7 to 8 years 400
from 9 to 12 700
from 13 to 15 630
from 16 to 17 540
18 и > 210

By the age of 15-16 years in children, the concentration of total IgE gradually
rises, then should gradually decrease.

Increased total immunoglobulin E

Here is an incomplete list of conditions manifested by an increase in overall
immunoglobulin E:

  • allergic rhinitis, rhinosinusitis;
  • bronchial asthma of atopic nature;
  • allergic dermatitis;
  • anaphylactic shock;
  • helminthiasis;
  • transplant rejection;
  • decreased immunoglobulin A;
  • aplasia of the thymus gland;
  • myeloma Ig E;
  • aspergillosis;
  • Viscott-Aldrich syndrome.
Conditions and diseases The reasons
Atopic diseases:

  • Allergic rhinitis
  • Bronchial asthma
  • Atopic dermatitis
  • Allergic Gastroenteropathy

Anaphylactic Diseases:

  • Urticaria – angioedema
  • Systemic anaphylaxis
Allergens:

  • dust
  • dustца
  • epidermal
  • food
  • metals
  • chemical compounds
  • medication
  • alien protein
  • Helminthic invasions
  • Fungal infections
IgE antibodies as a protective immune response
  • Bronchopulmonary aspergillosis
  • Whiskott Aldridge Syndrome
  • Di-Georgi syndrome
not yet known
  • Joba syndrome,
  • IgA deficiency
  • Reaction to the graft
T-suppressor defect
multiple IgE – myeloma Neoplasia of IgE-producing plasma cells

The highest levels of immunoglobulin E are observed in
patients suffering from multiple atopy (for example,
bronchial asthma, dermatitis, allergic rhinitis), and
with multiple allergies.

But even if you identify hypersensitivity to 1-2
allergens, total immunoglobulin E may remain in
limits of normal.

Specific immunoglobulins E

The definition of total immunoglobulin E makes it clear whether
hypersensitivity, sensitization, or
not. Even with his increased level of allergy symptoms in humans
may not be until there is contact with the allergen.

Increased immunoglobulin E level over 200 IU / ml most often
says that the patient is allergic. Which ones
This allergy can only be detected in children from 3 years old, not
earlier. This will be the study of allergen-specific IgE.

Detection of increased specific IgE in the blood will give
the ability to prevent an asthma attack or the development of pollinosis, so
how can you find out the “culprit” and avoid contact with him.

Skin tests

Diagnosis consists in conducting skin allergy tests – these are tests,
which are applied on the skin, application, but more often
всего путем скарификации. This application scarificator
�”Scratches” on the forearm, on each of which a certain drip
diluted sterile allergen (they are signed directly on the arm,
abbreviated). Allergen that within 15 minutes after application
caused reddening more than 0.8 cm in diameter, consider the cause
allergies.

Blood test specific IgE

  • ELISA – enzyme-linked immunosorbent assay (ELISA);
  • RAST – radioallergosorbent test.

Indications for blood tests for specific IgE:

  • children over 3 years old;
  • frequent recurrence of the disease;
  • intensity of allergic manifestations cannot be undone
    hormones and antihistamines;
  • contraindications for skin tests;
  • false + and false results of skin tests;
  • inflammation of the skin;
  • urticaria – when after mechanical irritation on the skin
    There are pictures of the pimples.

Rate reduction

The decrease in the level of immunoglobulin E noted with a defect
T lymphocytes. It occurs in diseases like
ataxia telangiectasia.

In conclusion, I would like to say that the definition of the level of Reagin –
This is not all that is needed for diagnosis. Result of this
analysis is compared with the clinical picture of the disease, inspection,
skin tests and other survey data.

Автор: Кривега Мария Салаватовна врач-реаниматолог

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