Furazolidone: instructions for use,contraindications, indications, dosage

Update: October 2018

Furazolidone is an antimicrobial and
antiprotozoan action, nitrofuran derivative
synthetic origin. Is an enzyme inhibitor
monoamine oxidase.

It is prescribed for microbial and parasitic infections of the gastrointestinal tract,
urinary tract and skin as part of complex therapy.

Фармгруппа: Антисептики и противомикробные
drugs for the treatment of gynecological diseases (except
combination with glucocorticosteroids).

The composition of the drug, release form, price

One tablet of furazolidone contains 0.05 g of furazolidone.

  • Tablets of 50 mg, on 10 pieces in a planimetric cell-free and cellular
    Packing packed in cartons. In 1 pack of 10 (1
    blister) or 20 (2 blister) tablets.
  • Tablets number 10: 44-62 rubles.
  • Tablets number 20: 80-130 rubles.
  • Furazolidone granules. Suspension preparation,
    designed for children.
  • Furazolidone powder. Veterinary drug.

pharmachologic effect

According to the instructions for use Furazolidone, being
nitrofuran derivative, violates biochemical processes
microorganisms such as cellular respiration and the krebs cycle that
leads to destruction of the cytoplasmic membrane or membrane.
After several doses of the drug, even before the mass decay
microorganisms, there has been an improvement in the overall well-being of the patient,
which is associated with a decrease in the production of toxins by microbial
by cells.

  • Active against a broad group of gram-positive and
    Gram-negative microbes and protozoa: Giardia lamblia,
    Trichomonas spp., Shigella: dysenteria, boydii, flexneri, sonnei;
    Salmonella typhi and paratyphi, Klebsiella, Proteus, Enterobacter,
  • Inactive against pathogens anaerobic and purulent
  • Characteristically, the slow development of pathogenic flora resistance to
    this drug.
  • A distinctive feature of Furazolidone is the lack
    inhibitory effects on immunity.
  • As a result of taking furazolidone increases the ability
    leukocytes destroy microorganisms.

Pharmacokinetics: Good oral absorption.
administered. When inflammation of the meninges is well nest
cerebrospinal fluid, creating there a concentration equal to that in the blood plasma.
It is rapidly metabolized by the liver to form an amino derivative,
pharmacologically inactive metabolite.

Up to 65% of the drug is excreted by the kidneys, a small concentration
found in feces, equal to the therapeutic dose in relation to
etiological pathogens of intestinal infections.


Indications for use

  • Intestinal infections: paratyphoid fever, bacillary dysentery, food
  • Parasitic diseases: giardiasis.
  • Urogenital tract infections: pyelitis, trichomonas urethritis,
  • In surgery: burns and infected wounds.


Absolute: hypersensitivity to nitrofuranam, chronic
end-stage renal failure, pregnancy and
breastfeeding period, children up to 12 months.

Relative (drug is prescribed with caution): deficiency
the enzyme glucose-6-phosphate dehydrogenase, chronic renal
failure, pathology of the nervous system and liver.


The drug is applied orally, after a meal with a lot of
water (except for local use in surgical pathology).
Treatment should not be more than 10 days.

Intestinal infections Parasitic diseases Urinary tract infections In surgery
100-150 mg four times a day for 5-10 days after meals.
The maximum daily dose of 800 mg.
  • Adults: 100 mg 4 times a day;
  • children – based on a daily dose of 10 mg per 1 kg of weight, distributing
    3-4 reception daily dose.

Maximum daily dose for adults 800 mg, maximum
single – 200 mg.

At 100 mg 3-4 times a day for 3 days. Местно, раствором фуразолидона   в соотношении 1:25000
irrigate lesions or apply to wet dressings.

Side effect

  • GIT – Reduced appetite, until the complete absence, nausea,
  • Nervous system – Neuritis and polyneuritis (with prolonged
  • Skin – Angioedema, skin rash,
    redness and itching of the skin.

Передозировка:  токсический гепатит, полиневрит. With
prescribed overdose of the drug is canceled, appointed
drink plenty with symptomatic therapy: antihistamines,
enterosorbents, vitamins of group B.

Drug interactions

  • In combination with ethanol containing drugs or alcohol
    disulfiram-like reactions may develop: fever, redness
    persons, falling blood pressure, difficulty breathing, tachycardia, nausea, fear
    death panic
  • In combination with antidepressants, ephedrine, MAO inhibitors,
    Phenylephrine, amphetamine, tyramine is likely a sharp increase.
  • While taking chloramphenicol and ristomycin furazolidone
    provokes the oppression of blood formation.
  • With одновременном приеме с аминогликозидами и тетрациклинами
    antimicrobial properties of furazolidone are enhanced.
  • Urine alkalizing drugs reduce effectiveness
    furazolidone, and acidifying – increase.

Special indication

For the prevention of neuritis if necessary, long
use in parallel appointed vitamins of group B.

Справочно: Нитрофураны, в том числе
Enterofuril, Furazolidone and others are banned in the EU countries and the USA.
since ostensibly with prolonged use increases the risk
cancer of the kidneys (but for a long time it is not
appoint). It is possible that this lobbying is more expensive (in
a dozen times) and broad-spectrum toxic antibiotics –
fluoroquinolones, which are becoming very popular and active
appointed in the European Union and America. Fluoroquinolones today are
reserve drugs for multiple tuberculosis
drug-resistant, and therefore active lobbying and
the administration of fluoroquinolones to treat any disease (when
You can do with other drugs) is dangerous. It puts at risk
treatment efficacy of drug-resistant tuberculosis, which
Russia is now growing (see tuberculosis problems, as
transmitted tuberculosis).

Автор: врач-гигиенист, эпидемиолог

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