Eye drops with a broad spectrum antibioticantibacterial action

Update: October 2018

Very many people do not like to take pills, not without reason
considering them harmful to the liver, kidneys, stomach and pancreas
glands. Tablets nasty chew hard to swallow, it is not clear what and
in what quantities to drink.

Then they are taken before meals, then after. Whether it’s a drop. Dripped
pipette or vial and live with a feeling made for health
debt.

Drops are a unique dosage form that, by its
the structure fits perfectly with the physiological needs of the eye
in constant cleansing and moisturizing.

In parallel, they bring in a different conjunctival sac.
medicinal substances that are simply absorbed here
and penetrate to virtually any of the eye structures and membranes.

About eye drops with broad-spectrum antibiotics and
antiseptics used to treat bacterial inflammation of the eyes
we will tell further. Eye drops with a broad spectrum antibiotic действия

How to drip eyes

  • Prepare two sterile wipes.
  • Thoroughly wash your hands or treat them with an antiseptic.
  • Shake the vial with drops several times.
  • Open drops.
  • Head thrown back.
  • Lower eyelid pull down.
  • Turn the medicine bottle vertically downwards with the other hand.
    and drip the required number of drops into the conjunctival sac behind the lower
    eyelids, gently pressing with your fingers on the bottom of the bottle.
  • Release the eyelid, close the eye.
  • Put a sterile cloth on the closed eye.
  • Gently press the inner corner of the eye with your finger and hold
    a few minutes.
  • Repeat the procedure for the other eye.
  • Close the vial.
  • In case of accidental excess of drops, you can wash
    eye water.
  • During the course of treatment, soft lenses are not recommended.
  • Lenses can be put on, fifteen minutes after
    instillation.
  • Within half an hour after the procedure it is not recommended to sit at
    steering wheel or work with increased danger equipment.

Types of drops

Eye drops for antibiotic eye inflammation are more commonly used.
for the treatment of bacterial infections, less often – for combined
viral-bacterial or fungal. Antibiotic eye drops
with antimicrobial action are called antiseptics.

All variety of antibacterial drops is divided into:

  • Drugs with a narrow action (affect a specific group
    pathogens)
  • Drug broad-spectrum (universal in relation to
    several infectious agents),
  • Combined (combinations of antibiotic and, for example,
    anti-inflammatory)
  • Universal (for example, antiseptics).

For children, the drugs of choice are

  • Sulfacyl sodium (Albucid) – a universal remedy, with small
    side effects, cheap and effective.
  • Vitabact and Okomistin are not antibiotics, but antiseptics, more
    sparing and do not cause allergies.
  • Fuzzitalmik — полициклический антибиотик, достаточно
    expensive.
  • Tobrex is an antibiotic aminoglycoside, not expensive, only
    prescribed by a doctor.
  • As for eye drops with fluoroquinolone antibiotics
    (Normaks, Tsiprolet, Vigomax, etc.), the question of their application in
    pediatrics is not straightforward. Up to 12 years is not advisable to use.
    children, although in some cases the ENT may assign them to a child even
    after a year.

Drugs with one type of antibiotic

Fuzzitalmik

капли в глаза с антибиотикомFuzzitalmik (510 руб.) — это
Fusidic acid micronized, polycyclic antibiotic.
Indications: Bacterial infections of the eye (blepharitis, conjunctivitis,
keratitis, dacryocystitis).
Противопоказания: гиперчувствительность, консервант
(benzalkonium chloride), which is part, is a potential
an allergen. Side effects: swelling of the eyelids, burning, itching, tearing,
conjunctival hyperemia, soreness, exacerbation
conjunctivitis. Application: 1 drop 2 p / day for 7
days

Levomycetinum drops

  • Levomitsetin 15 rub.

левомицетиновые каплиThese eye drops contain 2.5 mg.
chloramphenicol in 1 ml solution. Another name is Chloramphenicol.
0.25%. Available in bottles of 5 and 10 ml. Refers to
antibacterial external means of a wide range of activity.
Disrupts the production of intracellular protein microbes.
Показания: конъюнктивит, кератит, блефарит, вызванные
Gram-positive flora (staphylococci, streptococci,
bacteroids) and gram-negative E. coli,
iherisinia, we protect. Since the resistance to the remedy
bacterial cells develops slowly, possibly repeated
use of the drug. Противопоказания:  проблемы с
blood formation, anemia, psoriasis, fungal infections, pregnancy
any trimester, infancy, intolerance.
Undesirable for use in lactating and children up to 4 years.
Side effects эффекты: аллергический конъюнктивит и блефарит.

Vigomax, Maxifloks

Active ingredient – antibiotic fluoroquinolone moxifloxacin
hydrochloride.

  • Vigamoks 190-230 rub
  • Maxiflox 150 rub.

вигомакс капли Blocks the enzymatic activity of the bacteria,
obstructing its division. Bactericidal for a large number
gram-positive and gram-negative bacteria, anaerobes,
acid-resistant and atypical microbes: cocci, listeria, chlamydia,
moraxella, legionell, mycoplasma, intestinal sticks, protea.

When instillation of eye drops in the conjunctival sac preparation
absorbed into the systemic circulation, but only slightly (1000 times
less than 400 mg taken orally). From the body acting
substance is removed in about half a day. Main indication
– conjunctivitis, including in the program of genital infections.
Противопоказания:  возраст меньше года, грудное
feeding, pregnancy, intolerance. Side effects
эффекты:
раздражение глаза, его сухость, покраснение, боль,
less commonly, systemic allergies (angioedema, anaphylaxis). In 0.1%
cases – corneal inflammation, loss of vision. Systemic side
effects: tachycardia, shortness of breath, dizziness, nausea.
Features применения: по капле в глаз трижды в сутки
average rate of 5 days.

Tobramycin 0.3%

  • Tobreks 170-200 rub
  • Tobriss 150-180 rubles.
  • 120-140 rub.

тобрексAminoglycoside, suitable for the treatment of bacterial
conjunctivitis, blepharitis, keratitis, iridocyclitis,
dacryocystitis, and for the prevention of postoperative microbial
complications.

Contraindicated in case of intolerance to the active substance.
Side effects эффекты: аллергические реакции со стороны век и
conjunctiva, ulcerative lesions of the cornea. Features
применения:
не рекомендуются длительные (свыше 24 суток) курсы,
as they promote the growth of insensitive microbial flora and
fungi.

Oftakviks (Levofloxacin)

  • Oftakviks 220 rub.
  • Levofloxacin solofarm 80 rub.

глазные капли офтаквиксTreats, like mofloxacin, to
fluoroquinolones that disrupt bacterial DNA synthesis. Supports
therapeutic concentrations of antibiotic in the tear film from 4 to 6
hours

Indicated for the treatment of superficial infections of the eye and
prevent operative complications of bacterial
origin. WITHпособ применения: по 1-2 капли каждые 2 часа
(up to 8 times per day) during the first two days of treatment. AT
further up to the fifth day four times a day. Side effects
эффекты:
жжение глаз, снижение остроты зрения, слизистое
detachable. Less commonly: swelling of the eyelids, dry eyes, photophobia. System:
headache, runny nose. Contraindications, as for mofloxacin.

нормаксOther fluoroquinolones

  • Normaks 160 rub (Norfloxacin)
  • Floksal 200 rub. (Ofloxacin)
  • Okatsin (Lomefloxacin)
  • Cipromed 140 rubles, Ciprolet 60 rubles (Ciprofloxacin 40 rubles)

Like Levofloxacin, these are eye drops.
fluoroquinolones, of different generations with high efficiency and wide
spectrum of activity. ATсе они не рекомендуются беременным, кормящим,
babies of the first year of life and undesirable in children under 4 years. Have
similar indications, side effects, methods of use.

Gentamicin Sulfate

гентамицинаAminoglycoside in 5 ml vial. Breaks synthesis
bacteria proteins.

Эффективность: действует на кокки, в том числе,
золотистый стафилококк, устойчивые к пенициллинам, AT связи с этим
can be used to treat nosocomial infections and after
операционных complications. Gives slow drug development
sustainability. ATарианты бактерий, не чувствительных к тобрамицину,
Neomycin also does not respond to gentamicin. When applied topically
not absorbed into the blood. Indications: конъюнктивит, блефарит,
iridocyclitis, dacryocystitis. Режим терапии: 1-2 капли 3-4 раза
per day for no more than 2 weeks.
Противопоказания: непереносимость. Caution is prescribed
with damage to the auditory nerves and pathologies of the kidneys. Side effects
реакции:
слезотечение, сыпь, покраснение и отечность глаз. With
long-term therapy is the risk of developing drug resistance and
fungal eye disease. Особые указания: у беременных
appointed only in cases where the potential risk to the fetus
overlapped by the benefit to the mother. Can be used in lactating.
Cases of drug overdose are not described.

Antibiotic combinations:

  • Ориприм-П (Полимиксин AT и Триметоприм),
  • Colbiocin (Tetracycline with Chloramphenicol and Colistimetatom
    sodium).

Antibiotics supplemented with glucocorticoid
anti-inflammatory drugs

  • Макситрол (Полимиксин AT, Неомицин и Дексаметазон),
  • Dexone (Neomycin with Dexomethasone),
  • Tobradex (Tobramycin and Dexomethasone),
  • Garazon (combination of Gentamicin and Betamethasone),
  • Dexagamtamycin (Gentamicin + Dexamethasone),
  • WITHофрадекс (Грамицидин WITH + Дексаметазон + Фрамицетин).

Tobradex тобрадекс

Price about 450 rubles. This combination of 3 mg Tobramycin and 1 mg
glucocorticoid dexamethasone. Antibacterial effect is enhanced
anti-inflammatory and anti-allergic. Combination reduces
doses of major components and reduces potential risks from
components, reducing their absorption. Indications:
conjunctivitis, keratitis without damage to the corneal epithelium,
blepharitis, prevention of complications after surgery.
Дозы: по две капли в конъюнктивальный мешок через каждые 4-6
hours AT первые 2 суток можно капать препарат каждые 2 часа.
Side effects: аллергия глаз, повышение внутриглазного давления,
headache, decreased vision. With длительном приеме растут риски
fungal or resistant bacterial infection.
Противопоказания: вирусные, грибковые и туберкулезные
lesion, condition after removal of a foreign body from the cornea,
individual intolerance. Does not fit lactating. Have pregnant
appointed only if the risk to the fetus is less beneficial to
mothers.

The universal tool of a broad spectrum is
Albucidum (sodium sulfacyl)

If the question arose: Which drops in the eye are cheaper, faster and
safer ?, – feel free to choose albumin.

Sulfacyl Sodium (Albucid)Антибактериальные капли в глаза

20-50 rub. The drug in vials or pipettes is easy to use,
active against most bacteria (gonococci, strepto and
staphylococcus, Escherichia coli), suitable for children (including
newborns) and pregnant women. Almost the only thing is
individual intolerance or allergy to sulfonamides,
manifested in redness and itching of the eyelids and conjunctiva.

In persons over 65, prolonged use of albucide may result
to blood disorders. Also, long-term therapy is not indicated.
with severe hepatic or renal failure. WITH
caution drug should be prescribed in persons receiving
diuretic type of furosemide and patients with diabetes mellitus second
types treated with sulfonylurea derivatives (Glibenclamide,
Gliclazide).

The active ingredient of the drug is 20% or 30% sulfacetamide,
supplemented with distilled water, sodium thiosulfate and
hydrochloric acid. Due to the excellent solubility in water
the active substance simply penetrates the main media of the eye and can
used for the treatment of purulent bacterial conjunctivitis, ulcers
corneas, keratitis, in the complex therapy of blepharitis, barley and
for the prevention of blenorrhea (gonococcal eye disease) in
newborns. Это средство номер один от конъюнктивита для
детей всех возрастов.

Albucidum should not be prescribed in patients receiving
Methotrexate, Cyclosporine, anticonvulsants, indirect
anticoagulants.

Antiseptics

The task of antiseptics is the physical elimination
infections in order to: prevent infection from penetrating deep into
organism. Antiseptic handles wounds, burns and mucous membranes
shell, including the eyes. Antiseptic drug destroys
almost all types of microorganisms:

  • bacterial infection
  • most viruses
  • fungal infection
  • and the simplest.

The advantage of this group of funds is that they do not
have a systemic effect and a little allergenic, which in turn
leads to a small number of contraindications. Since antiseptics
only have a local effect, you can use them
pregnant and lactating women, newborns. But how
known, not without its disadvantages, which is
that drugs have high local aggressiveness, which is essential
narrows their range of use.

The following antiseptics are most widely used for the eyes:

Окомистин и ATитабакт

  • антибактериальные глазные каплиATитабакт – раствор
    picloxidine.
  • Okomistin is Miramistin.

Indications: Антисептические глазные препараты используются в
following cases:

  • with inflammation of the cornea,
  • in the case of conjunctivitis,
  • inflammation of the eyelids (diseases such as blepharitis or
    barley),
  • for the prevention of complications that appear in the postoperative
    or post-traumatic period.

антибактериальные

Contraindications to this drug is an allergic
reaction or hypersensitivity. If after applying
These drops cause such unpleasant symptoms as: swelling
tissues surrounding the eye, sharp pain, tearing, or painful
спазм век, необходимо прекратить use of the drug.

Indications for treatment with antibiotics

Conjunctivitis

This is an inflammation of the outer lining of the eye, accompanied by
redness, tearing, feeling of sand in the eye, photophobia
most often has an infectious nature. With бактериальном процессе
most often there is purulent discharge from the eyes (yellow or
green). Withмерами бактериального конъюнктивита становятся
staphylococcal processes, gonococcal conjunctivitis.

If conjunctivitis is viral (measles, rubella,
adenovirus infection, herpes, etc.), then discharge
слизистое и показаны противовирусные средства. Allergic
conjunctivitis requires anti-allergic drops.

Keratitis

AT комплексной терапии, когда присоединяется инфекция, при данных
diseases also show local antimicrobials and
broad-spectrum antibiotics.

Edematous forms of keratitis are often associated with gram-negative
microflora, often complicate the misuse of lenses.
Creeping corneal ulcers are associated with injuries to the shell and
secondary infection. Pathology is characterized by pain in
eyes, photophobia, eyelid spasm, reduced visual acuity, clouding
eyes, corneal ulceration. With глубоких кератитах могут
remain cicatricial changes with a persistent drop in sharpness
view.

Uveitis

Speaking of uveitis, mean choroid inflammation.
eyes. AT зависимости от того, какой отдел сосудистого тракта
inflamed, distinguish:

  • Iridocyclitis is called the lesion of the anterior segment (rainbow
    shell and ciliary body),
  • Peripheral uveitis affects choroid, retina, ciliary
    and vitreous body.
  • Rear uveitis – choroiditis (inflammation of the choroid) or
    chorioretinitis (inflammation of the choroid and retina).

To manifest such pathologies will become pain in the eye, photophobia,
lacrimation. reduced visual acuity or swimming dark spots
before your eyes. The basic principles of uveitis treatment coincide with such
with keratitis.

Автор: Кривега Мария WITHалаватовна врач-реаниматолог

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