Erespal: instructions for use of syruppills

Update: October 2018

Erespal (Fenspirid) is a drug with
bronchodilator and antispasmodic action, which is often
used in the treatment of bronchial asthma. It has
clinically proven ability to increase the activity of cilia
bronchial ciliated epithelium, normalize the amount of secretion
bronchi and reduce its viscosity. Effectively removes bronchial
obstruction, restores pulmonary gas exchange.

  • Not recommended for the treatment of pregnant and lactating women.
    Children from 2 years can be appointed only in the form of syrup.
  • Included in the list of essential medicinal
  • Available in two oral dosage forms.
    applications: syrup and tablets.


Drug with anti-bronchoconstrictor and anti-inflammatory
activity. Pharmacological group of active substance
drug (fenspirid): H1-antihistamines.

The composition of the drug

Active substance Excipients Shell


80 mg of fenspiride hydrochloride 104.5 mg of calcium phosphate, 100 mg of hypromellose, 0.5 mg
anhydrous colloidal silicon dioxide, 12.8 mg povidone-K30, 2.2
mg of magnesium stearate.
0.841 mg of titanium dioxide, 0.263 mg of macrogol 6000, 0.263 mg
glycerol, 0.263 mg of magnesium stearate, 4.37 mg of hypromellose.


 200 mg of fenspiride hydrochloride (for 1 ml of syrup -2 mg
500 mg of honey-flavored flavoring composition, 400 mg
vanilla tincture, 200 mg of licorice root extract, 10 mg
Sunset S dye yellow, 90 mg methyl parahydroxybenzoate, 22.5 g
glycerol, 60 mg of sucrose, 45 mg of saccharin, 35 mg
propyl parahydroxybenzoate, 190 mg of potassium sorbate, purified water to
volume of 100 ml.

Release form, price

  • Syrup Эреспал: прозрачная жидкость, имеющая оранжевый цвет, в
    brown plastic bottles of 150 or 250 ml, in
    carton package. Цена: сироп 150 мл – 210-264 руб, сироп 250 мл
    – 333-428 руб.
  • Pills Эреспал: белые круглые таблетки двояковыпуклой формы,
    coated, 15 pieces in a blister, in a cardboard bundle of 2
    блистера (30 pills). Price: 299-430 rub.

pharmachologic effect

According to the instructions for use Erespal, the active substance
drug – fenspirid – has a pronounced anti-inflammatory
and anti-bronchoconstrictor effect due to a decrease in
the production of basic biologically active substances that play a key
role in the development of the inflammatory response and bronchospasm: cytokines,
free radicals, arachidonic acid metabolites.

Inhibits arachidonic acid metabolism, simultaneously blocking
histamine H1 receptors, since it is histamine that stimulates
arachidonic acid conversion into the final
metabolite-factors of inflammation. Reduces the production of others
inflammatory mediators – serotonin and bradykinin.

Blocks α-adrenoreceptors, activation of which enhances
secretion of bronchial glands. Complex action of fenspiride
reduces the pathological influence of a number of factors contributing
hypersecretion of anti-inflammatory substances and causing obstruction
bronchial tree. It has a pronounced antispasmodic and
myotropic action.


The drug is well absorbed in the digestive tract. In the instructions Erespala
It is indicated that after oral administration 1 tablet maximum
the concentration of fenspiride in the blood is detected after 6 h,
the use of syrup determines the effective concentration already through
2,5 ч. Период полувыведения (Т 1/2) – 12 ч, выводится в основном
through the urinary system (up to 90%), a small part is derived
intestine (about 10%).

Indications for use

The drug is shown in the treatment of respiratory diseases
paths (upper and lower sections):

  • pharyngitis;
  • риноpharyngitis;
  • laryngitis;
  • tracheitis;
  • tracheobronchitis;
  • bronchitis (with or without chronic respiratory failure
  • bronchial asthma;
  • respiratory symptoms of influenza, measles and whooping cough;
  • sinusitis;
  • otitis;
  • respiratory infections that have a symptom complex


  • Hypersensitivity reactions to primary or secondary
    substances of the drug.
  • Pills – до 18 лет
  • Syrup – дети до 2 лет

Use in pregnant and lactating women

Erespal use during pregnancy and lactation is not recommended.
due to limited clinical safety data for data
categories of individuals. However, therapy with Erespal and its counterparts during
gestation is not a reason for artificial interruption
of pregnancy.


Syrup Эреспал

Pills Эреспал

Adults and teenagers over 18 years old For 45-90 milliliters (3-6 tablespoons, respectively) in
По 1 таблетке (80 мг) дважды-трижды в day. Maximum dose
на суточный прием – 240 мг (3 таблетки).
Children from 2 years old – at the rate of 4 mg per 1 kg of weight.

Children up to 10 kg: 10-20 milliliters (2-4 tsp.
соответственно) в day.

Children more than 10 kg: 30-60 ml (2-4 tablespoons, respectively) per

special instructions It is taken before meals. Before use, be sure to
shake up For younger children age is allowed to be added to
bottle with food or drink.
It is taken half an hour before meals with water.
Duration of treatment The doctor determines

Side effect

  • The main adverse reactions during therapy with Erespal are observed with
    side of the digestive tract: gastrointestinal disorders, pain in
    epigastric region, nausea, vomiting, slightly less marked
    diarrhea and vomiting.
  • From the CCC can tachycardia, palpitations,
    uncritical drop in blood pressure.
  • From the side of the central nervous system is likely to develop drowsiness and
  • Skin: urticaria, erythema, angioedema,
    pruritus, epidermal necrolysis of a toxic nature.
  • General disorders: asthenic phenomena, increased
  • Additionally for syrup: hypersensitivity reactions to
    sunset dye yellow s


При приеме сиропа или pills в дозе более 2320 мг –
immediately contact a medical facility. Symptoms:
agitation or drowsiness, lethargy, nausea and vomiting,
tachycardia with accelerated sinus rhythm.

Drug interactions

Due to the possibility of an adverse reaction in the form
sedation is not recommended to combine Erespal with
drugs with sedative activity, and alcohol.

special instructions

The presence of parabens in syrup may trigger the development
allergic reactions (immediately after taking and

Patients with diabetes should consider the presence in the composition
sucrose: in 1 tsp – 3 г (0.3 ХЕ), 1 ст.л. contains 9 g (0.9

During treatment with Erespal, due to possible sedatives.
reactions require caution when control is needed
vehicles, working with precise mechanisms and
activities requiring a high reaction rate.

Shelf life and storage

Valid for 3 years from date of manufacture. Special conditions
storage is not required. When storing the syrup, sedimentation is likely to occur,
disappearing when shaken and not affecting activity.

Analogs of Erespala

Siresp, Eladon, Inspiron, Fosidal, Fenspirid.

Автор: врач-гигиенист, эпидемиолог

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