Enterofuril: instructions for use,indications, contraindications, dosage

Update: December 2018

Enterofuril is a drug used to treat diarrhea.
infectious origin.

The advantages of its use:

  • Enterofuril does not disturb the balance of the normal microflora of the digestive tract,
    since it is practically not absorbed from the intestinal tract,
    showing an antibacterial effect only in the intestinal lumen.
  • Also, with viral diarrhea, Enterofuril reduces the risk of developing
    bacterial superinfection.
  • Possible use in infants older than 1 month (except
    premature).
  • Perhaps (according to indications) the use of Enterofuril at
    of pregnancy.
  • The drug does not penetrate into breast milk, so it may
    prescribed during breastfeeding.
  • It has high clinical efficacy.
  • The drug is fairly safe and good.
    is transferred.
  • It is produced in the form of capsules and suspensions (which is convenient for treating
    little children)

Pharmachologic effect:

The instructions on the use of Enterofuril indicated that
broad-spectrum antimicrobial drug acting
substance – 5-nitrofuran derivative, nifuroxazide. Enterofuril
is a dose-dependent drug, that is:

  • medium and low doses have a bacteriostatic effect,
    caused by inhibition of dehydrogenase activity when in
    bacterial cell, the biosynthesis of the necessary compounds is disturbed,
    while blocking the respiratory chain and bacterial cell
    losing the ability to multiply.
  • high doses – bactericidal action, since high
    dosages destroy the cell membrane of bacteria. If violated
    the integrity of the cell membrane, then pathogenic death occurs
    bacteria.

Также Enterofuril угнетает продукцию патогенными бактериями
exotoxins, therefore, reduced irritation of epithelial cells
intestines and the release of fluid in the intestinal lumen decreases.
In addition, the drug helps to increase phagocytic activity
and activates immunity. When taking this antimicrobial agent
it creates a high concentration in the intestines, displayed
Enterofuril с калом.

Active against the following causative agents of gastrointestinal infections:

  • Gram-positive microorganisms: Streptococcus pyogenes,
    Staphylococcus pyogenes, Clostridium spp .;
  • Gram-negative enterobacteria: Klebsiella spp., Escherichia
    coli, Shigella spp., Salmonella spp, Enterobacter spp.,
    Yersinia spp., Vibrio cholerae, Citrobacter spp., Edwarsiella spp.,
    Campylobacter spp.

Поскольку Enterofuril не оказывает влияния на сапрофитную
(non-pathogenic) flora, disequilibrium normal intestinal
flora does not occur. That is, after applying dysbacteriosis
arises.

Composition and release form

Капсулы Enterofuril — нифуроксазид 100 мг

Capsules: hard gelatin, opaque, yellow,
the contents are yellow powder. Excipients: sucrose,
corn starch, powdered cellulose, magnesium stearate.
Shell composition: gelatin, titanium dioxide (E171), cosine red
(E124), orange yellow (E110), quinoline yellow (E104), azorubine
(E122).

Средняя цена Enterofurilа 100mg 30 caps in pharmacies: 230-260
rub.

Капсулы Enterofuril — нифуроксазид 200 mg

Capsules: solid opaque gelatin, yellow,
contents – yellow powder possible with inclusions of small pieces
compressed mass. Auxiliary substances: cellulose
powdered, sucrose, magnesium stearate, corn starch.
Shell composition: gelatin, titanium dioxide (E171), azorubine (E122),
quinoline yellow (E104), cosine red (E124).

Средняя цена Enterofurilа 200мг. 16 caps in pharmacies: 270-300
rub.

Enterofuril суспензия для приема внутрь — нифуроксазид 200 mg

Suspension: yellow, thick, with a smell of banana
Excipients: distilled water, sucrose, citric
acid, sodium hydroxide, methyl parahydroxybenzoate, carbomer,
ethanol 96%, banana flavoring.

Средняя цена Enterofurilа 200мг. суспензия: 400-500 rub.

Indications for use

  • acute diarrhea infectious genesis
  • chronic bacterial diarrhea (with helminthic invasion
    the drug does not apply)
  • chronic diarrhea with colitis
  • antimicrobial diarrhea
  • according to indications may be prescribed for diarrhea not known
    etiology

Противопоказания Enterofurilа

Согласно инструкции по применению Enterofuril противопоказан:

  • newborns (up to 1 month)
  • premature babies
  • children under 7 years old – in the form of capsules
  • hypersensitivity to nifuroxazide and other derivatives
    nitrofurans

Способ применения и дозы Enterofurilа для детей и взрослых

  • Суспензия: детям до 2 лет Enterofuril показан только в виде
    suspension, which before use should be well mixed. For
    Accurately determine the dose using a special measuring spoon.
  • Capsules: used from the age of 7 years, not a capsule
    It is recommended to divide, it should be swallowed whole, drinking large
    amount of water.

Enterofuril можно принимать независимо от приема пищи,
the duration of treatment is not more than 7 days.

Age Dosage Reception ratio Maximum Daily Dose
children 1-6 months 100 mg (1/2 scoop or 2.5 ml) 2-3 p / day 300 mg
дети 7 months-2 лет 100 mg (1/2 scoop or 2.5 ml) 4 p / day 400 mg
children 2-7 years old 200 mg (1 scoop) 3 r / day 600 mg
over 7 years old and adults 200 mg 4 p / day 800 mg

Side effects

Usually the drug is well tolerated by patients, in some
cases of individual intolerance may develop
allergic reactions (see urticaria).

Overdose

There are no specific signs of overdose. When taking high
doses, non-specific therapy is indicated: gastric lavage, then
intake of enterosorbents (Polysorb, enterosgel, activated carbon,
Filtrum STI, etc.)

Применение Enterofurilа при беременности

During pregnancy, this drug is not contraindicated and may
its use according to indications in a situation where the expected benefit to
mother exceeds the possible threat to the fetus. Currently
information about the negative impact of nifuroxazide on the developing fetus
not. Поскольку Enterofuril в грудное молоко не проникает, его можно
use when breastfeeding.

Interaction with other drugs

Since the drug is not adsorbed in the lumen of the digestive tract,
interaction with other drugs is unlikely. but
the use of alcohol and drugs containing ethyl alcohol,
одновременно с Enterofurilом не допустимо. Also not
рекомендуется  принимать препарат одновременно с сорбентами,
because reduced its effectiveness.

Storage conditions

Store at room temperature.

special instructions

Кроме использования Enterofurilа при лечении диареи одновременно
rehydration therapy should be carried out (oral or
intravenously) according to the degree of dehydration and general
condition of the patient. The drug is used only for its intended purpose.
doctor, before use, you should read the instructions on
применению Enterofurilа.

Аналоги Enterofurilа

Today the following analogs are registered
Enterofurilа (действующее вещество Nifuroxazide): Ersefuril,
Nifuroksazid, Ekofuril, Stopdiar, Lekor.

Ersefuril Stopdiar  Ecofuril  Nifuroxazide Lekor
  • Ersefuril

200 mg. 28 pcs. 600-700 rub.

  • Stopdiar

суспензия 280-300 rub., табл. 24 pieces 100mg 160-230 rub.

  • Ecofuril

30 caps 100 mg. 250 руб, 30 caps 200 mg. 360 rub.

  • Nifuroxazide
  • Lekor

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