Causes of increased alkaline phosphatase in the blood.Symptoms and treatment


  • Why does alkaline phosphatase increase in blood?
  • Natural causes of alkaline phosphatase
    is raised
  • Why is schP increased in pregnant women?
  • Symptoms of increased alkaline phosphatase
  • The mechanism of raising the level of alkaline plates
  • When an analysis is prescribed to determine that alkaline phosphatase
  • How to prepare for blood donation for alkaline phosphatase?
  • Video
  • When is alkaline phosphatase reduced?

Щелочная фосфатаза — необходимый компонент
the body’s enzyme system, it is important to know if it is elevated, that
This means and what affects. This parameter is determined by
biochemical analysis of serum. In itself a change towards
increasing or decreasing alkaline phosphatase does not mean the presence of a specific
diseases, however this indicator is very valuable for

Why does alkaline phosphatase increase in blood?

The normal content of alkaline phosphatase, detected by biochemical analysis,
ranges from 45 to 148 grams per mole. What does it say
exceeding the specified level? Increased alkaline phosphatase in the blood
has certain reasons:

  • features of a healthy body;
  • liver pathologies: cirrhosis, hepatitis (also with hepatitis B and
    C), tumors, the postoperative period;
  • diseases of the gastrointestinal tract;
  • infectious lesions of the digestive system;
  • ulcerative colitis;
  • gallstone disease and diseases of the biliary tract;
  • infectious mononucleosis leading to decreased function
    the liver;
  • bone diseases, such as myeloma, rickets,
    osteomalacia, bone metastases;
  • myocardial infarction.

As can be seen from the above list, the cause of elevated enzyme
activity can be both pathology and feature relatively
healthy body as a variant of the norm.


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Natural causes of alkaline phosphatase бывает

Here are the states that increase the parameter in question, but not
are pathological:

  • hormonal changes (periods of growth and puberty,
    the end of the bone growth period);
  • the functioning of the placenta in late pregnancy;
  • recovery time in the postoperative period and after
    bone fractures;
  • treatment with certain drugs for example
    aspirin, antibiotics, paracetamol, oral
    contraceptives (here are those medicines that affect
    on a condition of a liver, than and increase the content of various enzymes in
  • certain age periods: children’s age in mind
    active growth in the elderly due to bone resorption
  • bad habits that adversely affect the liver: use
    tobacco and alcohol, substance abuse;
  • lack of adequate motor activity;
  • unhealthy eating habits (significant predominance in
    ration of fatty and saturated with trans-fat foods);
  • obesity.

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liver and what are the normal values ​​in women?

Если все остальные показатели на фоне того, что ЩФ raised, в
normal, the person is healthy, and the excess of the parameter in such
case – the individual version of the norm. Therefore, this state is not
requires correction and treatment.

IMPORTANT! Many of the conditions that cause an increase in enzyme levels
themselves are not pathological (bad habits, excessive
weight, hypodynamia), may subsequently cause harm to health,
therefore in these cases the patient’s lifestyle needs

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Why is schP increased in pregnant women?

Enhancement of enzyme activity during pregnancy is one of
manifestations of changes in this parameter for physiological reasons.
So, normally, there is always an excess of the content of this enzyme in
serum in the later stages of childbearing, that is, in the third

This increase in serum enzyme levels in pregnant women
due to the fact that at this time is actively growing and developing
the placenta, which is responsible for feeding the baby. And it provokes
increased metabolic processes, which is why phosphatase increases

ATTENTION! Moreover, a decrease in alkaline phosphatase in a pregnant woman is much more
serious problem because it indicates placental
failure, leading to hypoxia.

Однако это не означает, что когда raised ЩФ у беременной
women do not need to pay any attention. After all, excessive
excess enzyme levels may indicate such
pathological conditions, such as eclampsia (late-period preeclampsia).
In order to identify this, additional analyzes should be carried out.
since elevated levels of enzymes, in particular alkaline phosphatase, may
adversely affect the cells of the placenta.

щелочная фосфотаза у беременных


IMPORTANT! If a woman has health problems
gastrointestinal tract, biliary tract or liver before
getting pregnant means you need to pay more
пристальное внимание на то, что ЩФ raised в процессе подготовки к

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Symptoms of increased alkaline phosphatase

Parameters of enzyme activity shows biochemical analysis.
blood. For different age categories the norm of the content of this
substances in blood serum are:

Category Reference interval ALP
Children 0 – 1 years old 450 – 460 U / l
Children 1 – 3 years old < 280 Ед/л
Children 4 – 6 years < 270 Ед/л
Children 7 – 12 years old < 300 Ед/л
Teenagers 13 – 17 years old (boys) < 390 Ед/л
Teenagers 13 – 17 years old (girls) < 185 Ед/л
Men 35 – 105 U / l
Women 40 – 130 U / l

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If an increase in phosphatase level in
compared with the age norm, the therapist will refer the patient to
additional and surveys and to a specialized specialist.

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The mechanism of raising the level of alkaline plates

ALP is contained in many human tissues, and its greatest
number – in the intestinal mucosa, bone cells (osteoblasts), in
ducts of the biliary tract, in the developing placenta and in
glandular breast tissue during lactation. With this enzyme
phosphoric acid and its organic derivatives are broken down, which
occurs due to the high pH of the enzyme, that is, the corresponding pH
alkalis (for which this substance got its name). All this
necessary for the transport of phosphorus within the body.

The definition is usually used for diagnostic purposes.
activity of the liver and bone forms of the enzyme. Under what
diseases can occur enhanced release of alkaline phosphatase from the liver
and bones? Obviously, when those organs are exposed
destruction. That is why the identification of elevated levels in the blood
may indicate the presence of a definite diagnosis.

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When an analysis is prescribed to determine that alkaline phosphatase increased?

Why the doctor may order to pass the analysis to determine
alkaline phosphatase activity? The analysis is assigned in the following

  • during clinical examination and professional examination of citizens engaged in harmful
  • in the complex of preparations for operational
  • with jaundice;
  • if there are signs of damage to the liver, digestive tract and biliary
    Systems: abdominal pain (right under the ribs), itching, dyspeptic

ATTENTION! It should be remembered that determine whether the increased alkaline
phosphatase, can only be compared with the age norm, because
normal rates for child and adult significantly

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How to prepare for blood donation for alkaline phosphatase?

To get the most correct result, you need to pass
blood from a vein strictly on an empty stomach. Since the content of the enzyme in
the body is affected by the state of the liver, should be avoided before delivery
excessive load on it, namely:

  • fatty foods;
  • alcohol;
  • taking hepatotoxic drugs.

Compliance with these rules will help minimize the likelihood
a false result of biochemical research. Should also
notify the prescribing physician if you have
there are conditions predisposing to the fact that the content
alkaline phosphate in the blood rises, for example, pregnancy or
phase of healing of the fracture.

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