Update: December 2018 In classical medicine does not exist
a single concept of “analysis for rheumatic tests”, therefore, it is necessary to determine exactly
what diagnostic measures are not included in it
possible. Doctors include various procedures in this term, but
they are united by one thing – they are all aimed at identifying systemic
What is the status data? This is a whole group
pathologies in which most human organs are affected,
including connective tissue. These include joints, heart,
kidneys, vessels, skin, eyes, etc. Such diseases are found
seldom enough – on average, only 1% of the population suffers from them
RF. But if a doctor has a suspicion of systemic
pathology, surveys related to
What are systemic diseases?
This group includes a large number of diseases
united by one characteristic – they develop
autoimmune inflammation. This is a special pathological process, with
which causes a “mistake” in the work of the patient’s immunity. because of
this disturbance, antibodies begin to attack healthy tissues
organism, not bacteria, viruses and other harmful
Currently, the most common systemic
- Rheumatoid arthritis;
- Systemic lupus erythematosus;
- Urethroculosis syndrome (Reiter’s syndrome);
- Ankylosing spondyloarthritis (synonym – disease
- �”Dry” syndrome (Sjogren’s syndrome).
Significant causes of these pathologies
still remain unknown to modern science. Of all
diversity of harmful factors, one particular
bacterium – Hemolytic Streptococcus A. It has been proven that after
body immunity may be impaired, and
antibodies against normal cells and organs appear. This particular
microorganism is the main cause of rheumatic fever
Most tests are aimed at identifying
�”Wrong” antibodies. Since the development mechanism of all systemic
diseases quite similar, according to the results of surveys almost
It is impossible to make a final diagnosis – with various
pathologies may increase the same indicators. But if
take into account not only the laboratory data, but also the symptoms
– you can conduct an effective diagnosis.
When to get tested
In most cases, from the beginning of the flow
systemic disease until its detection takes several years
(on average 3-5 years). This situation develops by several
reasons, including due to difficulties with diagnosis and atypical
manifestation of pathology. It can be difficult for a physician to associate different
symptoms in one patient, especially if the patient presents
complaints about them at different times. Therefore, it is important that a person
attentive to his health and noticed characteristic
signs of autoimmune inflammation.
Contact your local doctor and take a blood test for
rheumatic tests should be in the following cases:
- If you feel morning stiffness in the joints of the hand or
the spine, which lasts longer than 30 minutes;
- If there is evidence of skin lesions, without any obvious
reasons. They may look like pockets of excess
dryness / flaking, punctate rash, persistent blanching or
- The presence of inflammation symptoms of several of the listed
organs: skin, heart (endocarditis or myocarditis); joints
(arthritis), kidney (diagnosis of nephritis), eye
If you have one of these situations, it should
seek medical help and carry out a full
diagnostics, including rheumatic tests.
Types of revision test
As noted above, there is no unambiguous interpretation of this term.
in classical medicine. Therefore, the question always arises which
Do you need tests for rheumatic tests? To diagnose any
systemic disease, most often, determine the following
- Rheumatoid factor – это особые антитела,
which are produced by cells of the immune system (leukocytes) and infect
connective tissue. Despite their name, their rise in
blood shows not only the presence of rheumatoid arthritis, but
and a number of other diseases;
- Anti-dna – еще одно вещество, которое
produce white blood cells in the presence of autoimmune inflammation. It
has a specific target, in contrast to the rheumatoid factor – the thread
DNA in cells where most of the genetic information is contained.
That is why the presence of anti-DNA in the blood leads to a large
the number of disorders in various organs;
- HLAB27 – специфический ген, который отвечает
for predisposition to a number of autoimmune pathologies, including
rheumatoid arthritis, ankylosing spondylitis, urethro-oculosis
syndrome and others. Its detection in a patient with characteristic
symptoms of one of the above diseases allows it
confirm in 90% of cases;
- Antinuclear factor – группа antibodies,
appearing in the blood in autoimmune pathologies. Their main goal
– cell nuclei, mainly of connective tissue organs.
About 10-20 years ago to the listed list of surveys
Often added markers that helped detect the transferred
former streptococcal infection: Antistreptolysin (ASL-O),
Antistreptokinase and Antistreptohialaluronidase. It helped
detect or exclude the presence of acute rheumatic fever
(rheumatism) in a patient. However, at present, this disease
practically disappeared in the Russian Federation, thanks to adequate treatment of infections
upper respiratory tract.
Preparation for analyzes
How to pass a test for rheumatic tests to reduce the likelihood
getting false results? This can only be done in one way.
– properly prepare for the study. Doctors, in this case,
give the following recommendations:
- To donate blood in the morning “on an empty stomach”, after 8 hours with
the moment of the last meal. If this is not possible,
it is allowed to carry out diagnostics in the afternoon, in 4 hours after a lung
- 2-3 hours before the study, you should exclude alcohol and
- On the eve of blood donation, it is necessary to limit the emotional and
Any other preparation for the diagnosis is not
required – these activities are sufficient for the patient.
Do not stop taking medicines recommended by a doctor or
interrupt other treatments prescribed on permanent
basis. Even if you are already diagnosed and you are taking
specific therapy that reduces the amount of antibodies in the blood – this
can not be done. Since the main purpose of diagnosis, in this case,
is to evaluate the effectiveness of treatment and the condition of the body on its
Decryption of analyzes
Laboratory tests can make search much easier.
true diagnosis. However, in order to be able to
to use, you should know the normal performance. Specific
studies for autoimmune diseases have one
similar trait – they are universal. Decoding revmoproved
the same for all people, regardless of gender and age. For this
use the following values:
|The studied indicator||Norm||High probability of pathology|
|Rheumatoid factor||Up to 30 IU / ml||More than 40 IU / ml|
|Anti-dna||Up to 20 IU / ml||More than 25 IU / ml|
|Antinuclear factor||Up to 1/160||More than 1/640|
|HLA B27||This is a qualitative result – the HLA B27 gene is either there or not.
Its absence indicates a low probability of developing autoimmune
|The presence of HLA B27 in combination with characteristic symptoms
The standards indicated in the table can be slightly revised.
vary, depending on the lab. This is due to the presence
various equipment, its calibration and consumables. AT
In most cases, the labs themselves write normal.
the values on the blanks with the results, but if they are not there, you can
use the data above.
The reasons for the increase in performance
Significant excess of standards
indicates the presence of an autoimmune disease, but which one?
Although they have low specificity, even
analyzes can suggest the most likely cause or group
reasons for increasing performance. To do this, enough
use the table below. AT ней отмечено,
exceeding what indicators should be expected at a certain
|Disease \ Indicator||Rheumatoid factor||Anti-dna||Antinuclear factor||HLA B27|
|Systemic lupus erythematosus||+||+||+||–|
|Sjogren’s disease||+||Чаще –||+||–|
The data should be worn in the diagnosis only
auxiliary character. AT первую очередь, всегда следует
focus on the human condition and the presence of symptoms of a lesion
various organs. Only considering all these signs it is possible with high
likely to suggest the correct diagnosis.
ATопрос: Могут ли быть все ревмопробы
negative in autoimmune disease?
AT редких случаях, такой вариант возможет. However, if available
typical signs and negative results of the study,
It is recommended to repeat the analysis, to exclude laboratory
ATопрос: Если в семье были случаи ревматоидного
arthritis, will it develop in children?
For any autoimmune inflammation, heredity plays
large role, but descendants passed only predisposition to
diseases, not the disease itself.
ATопрос: Это исследование проводится платно или
Unfortunately, only large medical institutions can
allow yourself to provide such expensive patients
diagnostics (especially in modern economic conditions).
Therefore, when contacting the municipal hospital, most likely
laboratory diagnostics will have to spend at their own expense. Average
the cost of each survey 500-2000 p.
ATопрос: Что will be, если пренебречь рекомендациям
a doctor and not do the specified tests?
The sooner chronic disease is detected, the more successful will be
лечение в последующем, тем дольше will be срок жизни человека и
the quality of his life.